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Journal of Spectroscopy
Volume 2013, Article ID 783457, 5 pages
Research Article

Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms

1Department of Chemistry, Government Danveer Tularam College, Utai, Durg, C.G. 490001, India
2Department of Chemistry, Government Nagarjun P.G. Science College, Raipur, C.G. 492001, India
3Department of Chemistry, Government College, Bhanpuri, Bastar, C.G. 494224, India

Received 5 May 2013; Accepted 11 July 2013

Academic Editor: Lahcen Bih

Copyright © 2013 Pankaj Soni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorptivity of the Fe(III)-SCN amitriptyline ion pair complex in terms of the drug lies in the range of (2.82–3.36) × 103 L·mol−1·cm−1 at the absorption maximum 460 nm. The detection limit of the method was 0.3 μg·mL−1. The slope, intercept, and correlation coefficients for the present method were found to be 0.008, 0.002, and +0.998, respectively. The effect of analytical variables on the determination of the drug and the composition of the complex are discussed in the paper. The method is applicable in the determination of amitriptyline in pharmaceutical preparations.