Simple Spectrophotometric Methods for Determination of Tenofovir Fumarate and Emtricitabine in Bulk Powder and in Tablets

Table 2

Accuracy and precision of the proposed spectrophotometric methods for analysis of TEN and EMT.

Analyte	Nominal value (𝜇g mL^−1)	Within-day (𝑛=9)			Between-day (𝑛=9)
		Found ± SD (𝜇g mL^−1)	RSD (%)	Er (%)	Found ± SD (𝜇g mL^−1)	RSD (%)	Er (%)
TEN (^1DR)	4.0	3.93±0.037	0.932	−1.801	3.94±0.031	0.798	−1.407
	8.0	7.89±0.036	0.461	−1.398	7.85±0.063	0.802	−1.852
	20.0	19.90±0.137	0.692	−0.513	19.86±0.111	0.559	−0.695
EMT (^1D)	0.5	0.49±0.003	0.668	−1.890	0.50±0.007	1.320	−0.756
	8.0	7.94±0.065	0.825	−0.732	7.96±0.082	1.028	−0.543
	40.0	39.89±0.131	0.328	−0.269	40.16±0.327	0.815	0.039