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Journal of Spectroscopy
Volume 2013, Article ID 970654, 6 pages
http://dx.doi.org/10.1155/2013/970654
Research Article

Chiral Solid Solutions for the NMR Analysis of Enantiomers: A Potential New Approach to Chiral Analysis

Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland

Received 10 June 2012; Revised 10 August 2012; Accepted 13 August 2012

Academic Editor: Eugen Culea

Copyright © 2013 Karel D. Klika. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Differences between the solid-state 13C CP-MAS NMR spectra of holemic samples of the two enantiomers of 2,2′-dihydroxy-1,1′-binaphthyl (binol) were not sufficiently emphatic to reliably distinguish them, though they are readily distinguishable from the spectrum of the bimate of the compound crystallized from an equimatic sample. Inducing an additional chiral environment by cocondensation with sucrose as a chiral selector (CS) provided a method to yield differential spectra for the two enantiomers and thus effect enantiodifferentiation by way of solid-state NMR using weak interactions from a CS.