Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry

Table 4

Pharmacokinetic parameters of muscone in rat serum after oral administration of artificial musk (625 mg·kg⁻¹, 𝑛=6)*.

Parameter	Estimate (mean ± SD)
𝑡max (min)	54±2.24
𝐶max (ng mL^−1)	695.33±68.35
AUC0→∞ (ng min mL^−1)	67456.03±7023.72
𝑡0.5 (min)	96.26±0.78
MRT (min)	198.91±23.72

^∗AUC_0→∞, the area under curve concentration-time; 𝐶_max, maximum concentration at 𝑡_max; 𝑡_0.5, elimination half life time; MRT, mean residence time.