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Journal of Spectroscopy
Volume 2014, Article ID 926268, 7 pages
http://dx.doi.org/10.1155/2014/926268
Research Article

Use of Novel Polyurethane Microspheres in a Curcumin Delivery System

1National Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, Hebei, China
2Qinhuangdao Entry-Exit Inspection & Quarantine Bureau Coal Inspection Technique Center, Qinhuangdao, Hebei, China

Received 13 May 2014; Accepted 31 May 2014; Published 4 August 2014

Academic Editor: Xinqing Chen

Copyright © 2014 Yongmei Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite having a wide range of beneficial pharmacological effects, curcumin is characterized by poor water solubility and absorption. In this study, novel polyurethane microspheres containing curcumin (Cur-PUMs) were prepared using carboxymethyl cellulose sodium to improve the bioavailability and prolong the retention time of curcumin. The prepared Cur-PUMs were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, and ultraviolet spectrophotometer. The sustained-release effects of Cur-PUMs were demonstrated using stability tests in vitro and in vivo pharmacokinetic studies following oral administration. We found that the stability of Cur-PUMs was strongly affected by pH variation. Further, compared with free curcumin, Cur-PUMs showed significantly improved maximum concentration and half-life.