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Journal of Spectroscopy
Volume 2015, Article ID 561919, 5 pages
Research Article

A Biomedical Surface Enhanced Raman Scattering Substrate: Functionalized Three-Dimensional Porous Membrane Decorated with Silver Nanoparticles

School of Science, Nantong University, No. 9 Se Yuan Road, Nantong, Jiangsu 226019, China

Received 4 September 2015; Accepted 10 November 2015

Academic Editor: Christoph Krafft

Copyright © 2015 Li Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We fabricated a simple, cheap, and functional surface enhanced Raman scattering substrate for biomedical application. Hot spots between two close silver nanoparticles distributed in the skeleton of a three-dimensional porous membrane, especially in the pores, were formed. The dual poles of micropores in the membrane were discussed. The pores could protect the silver nanoparticles in the pores from being oxidized, which makes the membrane effective for a longer period of time. In addition, Staphylococcus aureus cells could be trapped by the micropores and then the Raman signal became stronger, indicating that the functional surface enhanced Raman scattering substrate is reliable.