Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Figure 1

Schematic of the Raman system. One centered excitation fiber and seven surrounding collection fibers were configured as a bifurcated fiber. A power adjustable 785 nm laser source (maximum power: 350 mW) coupled with the excitation fiber was used as the excitation source, and a thermoelectrically (TE) cooled CCD camera coupled to a high-throughput spectrograph collects spontaneous Raman signals transmitted through the seven collection fibers.