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Journal of Spectroscopy
Volume 2017, Article ID 9253475, 6 pages
Research Article

Shot-Noise Limited Time-Encoded Raman Spectroscopy

1Department of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA, USA
2Institut für Biomedizinische Optik, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany
3Optores GmbH, Gollierstr. 70, 80339 Munich, Germany

Correspondence should be addressed to Robert Huber; ed.kcebeul-inu.omb@rebuh.trebor

Received 13 December 2016; Accepted 1 February 2017; Published 22 March 2017

Academic Editor: Christoph Krafft

Copyright © 2017 Sebastian Karpf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Raman scattering, an inelastic scattering mechanism, provides information about molecular excitation energies and can be used to identify chemical compounds. Albeit being a powerful analysis tool, especially for label-free biomedical imaging with molecular contrast, it suffers from inherently low signal levels. This practical limitation can be overcome by nonlinear enhancement techniques like stimulated Raman scattering (SRS). In SRS, an additional light source stimulates the Raman scattering process. This can lead to orders of magnitude increase in signal levels and hence faster acquisition in biomedical imaging. However, achieving a broad spectral coverage in SRS is technically challenging and the signal is no longer background-free, as either stimulated Raman gain (SRG) or loss (SRL) is measured, turning a sensitivity limit into a dynamic range limit. Thus, the signal has to be isolated from the laser background light, requiring elaborate methods for minimizing detection noise. Here, we analyze the detection sensitivity of a shot-noise limited broadband stimulated time-encoded Raman (TICO-Raman) system in detail. In time-encoded Raman, a wavelength-swept Fourier domain mode locking (FDML) laser covers a broad range of Raman transition energies while allowing a dual-balanced detection for lowering the detection noise to the fundamental shot-noise limit.