Using Compact ¹H NMR, NIR, and Raman Spectroscopy Combined with Multivariate Data Analysis to Monitor a Biocatalyzed Reaction in a Microreaction System

Figure 1

(a) Process flow-chart of the microreaction assembly: 1, Raman and NIR probe; 2, storage vessel containing the majority of the reaction mixture; 3, piston pump; 4, heat exchanger; 5, cartridge reactor; 6, temperature sensor; and then a compact ¹H NMR spectrometer is located in a bypass. (b) Picture of the microreaction platform (from left to right): inlet module, heat exchanger, cartridge reactor, T-sensor, optical flow cell, and outlet module. Raman probe and transflection NIR immersion probe (front).

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