The In Vivo Evaluation on Total Components from Extract of Aconitum Based on a New Analytic Method of Area under Absorbance-Wavelength Curve

Table 5

Pharmacokinetics parameters of total components (mean ± RSD, ).

Parameters	Unit	Single dose	Multiple dose
t1/2	h	4.056 ± 0.026	3.395 ± 0.049
Tmax	h	2.000 ± 0.054	2.000 ± 0.175
Cmax	µg/ml	8.210 ± 0.386	5.410 ± 0.404
AUC0∼12	µg/ml/h	24.555 ± 0.264	24.901 ± 1.594
AUC0–∞	µg/ml/h	69.731 ± 0.223	32.626 ± 1.601
CL/F	µg/ml/h	0.278 ± 0.092	0.682 ± 0.312
V1/F	mg/µg/ml	1.627 ± 0.123	3.338 ± 0.872
Cav	µg/ml	—	2.075 ± 0.282
AUCss	µg/ml/h	—	24.610 ± 0.422
DF	—	—	2.405 ± 0.175