Research Article
Low-Content Quantitation in Entecavir Tablets Using 1064 nm Raman Spectroscopy
Table 1
Contents of each tablet with different API concentrations in calibration samples and test samples.
| | API mass concentration | ETV-H (mg) | Lac-H (mg) | MCC (mg) | PVPP (mg) | PVP K30 (mg) | MgSt (mg) |
| | Calibration samples | | | | | | | | 0.1% | 0.2 | 120.7 | 65.1 | 8.0 | 5.0 | 1.0 | | 0.2% | 0.4 | 120.6 | 65.0 | 8.0 | 5.0 | 1.0 | | 0.3% | 0.6 | 120.4 | 65.0 | 8.0 | 5.0 | 1.0 | | 0.4% | 0.8 | 120.3 | 64.9 | 8.0 | 5.0 | 1.0 | | 0.6% | 1.2 | 120.0 | 64.8 | 8.0 | 5.0 | 1.0 | | 0.8% | 1.6 | 119.8 | 64.6 | 8.0 | 5.0 | 1.0 | | 1.0% | 2.0 | 119.6 | 64.5 | 7.9 | 5.0 | 1.0 |
| | Test samples | | | | | | | | Baraclude 0.25% | 0.5 | 120.5 | 65.0 | 8.0 | 5.0 | 1.0 | | Baraclude 0.25% | 1.0 | 240.0 | 130.0 | 16.0 | 10.0 | 2.0 | | 0.5% | 1.0 | 120.2 | 64.8 | 8.0 | 5.0 | 1.0 |
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