|
| Raman peaks | Vibrational assignments |
|
| Entecavir monohydrate (ETV-H) |
| 288 ma | Torsion vibration of NCNH, OHOC, and OHOH and bending vibration of H-O-H and OCN |
| 341 m | Bending vibration of CCO |
| 372 m | Torsion vibration of CCOH and out-of-plane deformation of NNNC and NCNC |
| 614 s | Bending vibration of CCC |
| 672 s | Torsion vibration of NCNC and NCNH and out-of-plane deformation of NNNC and OCNC |
| 885 m | Stretching vibration of OC and CC and bending vibration of CCH and NCN |
| 1065 m | Stretching vibration of OC |
| 1196 m | Stretching vibration of CC, NC, and OC and bending vibration of NCH |
| 1329 s | Bending vibration of OCH and torsion vibration of HOCH |
| 1387 s | Bending vibration of CCH and torsion vibration of CCCH |
| 1487 vs | Stretching vibration of NC |
| 1538 m | Stretching vibration of NC and bending vibration of CNC |
| 1580 s | Stretching vibration of NC and bending vibration of HNH |
| 1684 m | Stretching vibration of CC and bending vibration of HCH |
|
| Lactose monohydrate (Lac-H) |
| 355 vs | Bending vibration of O-C-C |
| 376 s | Bending vibration of H-O-H and bending vibration of O-C-C |
| 398 s | Bending vibration of O-C-C and out-of-plane deformation of O-C-C-C |
| 473 vs | Bending vibration of O-C-C |
| 852 s | Stretching vibration of O-C and out-of-plane deformation of O-C-C-C |
| 879 s | Stretching vibration of O-C |
| 915 s | Stretching vibration of C-C and O-C and out-of-plane deformation of O-C-C-C |
| 954 s | Stretching vibration of O-C |
| 1023 m | Stretching vibration of O-C |
| 1056 m | Stretching vibration of O-C |
| 1090 vs | Stretching vibration of O-C |
| 1124 s | Stretching vibration of O-C |
| 1138 s | Stretching vibration of O-C |
| 1220 m | Bending vibration of H-C-O and torsion vibration of HCCC |
| 1261 s | Bending vibration of H-C-O |
| 1334 s | Bending vibration of H-C-O |
| 1346 s | Bending vibration of H-C-O |
| 1472 s | Bending vibration of H-C-H |
|
| Microcrystalline cellulose (MCC) |
| 379 s | Bending vibration of H-O-H and bending vibration of O-C-C |
| 439 s | Out-of-plane deformation of O-C-C-C |
| 455 s | Out-of-plane deformation of O-C-C-C |
| 899 m | Out-of-plane deformation of O-C-C-C |
| 972 m | Stretching vibration of O-C |
| 998 m | Stretching vibration of O-C |
| 1036 m | Stretching vibration of O-C |
| 1063 m | Stretching vibration of O-C |
| 1094 vs | Stretching vibration of O-C |
| 1123 vs | Stretching vibration of O-C |
| 1154 s | Stretching vibration of O-C |
| 1380 s | Bending vibration of H-C-O |
|
| Crospovidone (PVPP) |
| 359 m | Bending vibration of O-C-C, C-C-N |
| 552 m | Stretching vibration of C-C and out-of-plane vibration of O-C-N-C |
| 752 s | Bending vibration of H-C-C and torsion vibration of H-C-C-C |
| 852 m | Torsion vibration of H-C-C-N |
| 899 m | Stretching vibration of C-C and bending vibration of CNC and CCN |
| 932 s | Torsion vibration of HCNC and CCNC |
| 1023 m | Stretching vibration of N-C and C-C and bending vibration of H-C-C, CNC, and CCN |
| 1227 s | Stretching vibration of N-C, bending vibration of H-C-C, and torsion vibration of H-C-C-C |
| 1298 m | Stretching vibration of N-C and bending vibration of H-C-C |
| 1369 m | Bending vibration of H-C-C and H-C-H, stretching vibration of N-C, and torsion vibration of H-C-N-C |
| 1425 vs | Bending vibration of H-C-H |
| 1451 s | Bending vibration of H-C-H |
| 1493 s | Bending vibration of H-C-H |
| 1673 s | Stretching vibration of C=C and O=C |
|
| Povidone K30 (PVP K30) |
| 364 m | Bending vibration of OCC and CCN |
| 559 m | Bending vibration of OCC and CCN and out-of-plane vibration of OCNC |
| 759 s | Stretching vibration of NC and CC and torsion vibration of HCCC |
| 852 m | Bending vibration of CCC and torsion vibration of HCCC and HCNC |
| 899 m | Stretching vibration of CC and bending vibration of CNC and NCC |
| 936 s | Torsion vibration of HCNC |
| 1003 m | Stretching vibration of CC and NC and bending vibration of HCC and OCC |
| 1025 m | Stretching vibration of NC and bending vibration of HCC and NCC |
| 1212 m | Bending vibration of HCN and torsion vibration of HCCN and HCNC |
| 1229 s | Stretching vibration of NC and bending vibration of HCC and HCN |
| 1347 m | Stretching vibration of NC and torsion vibration of HCNC |
| 1371 m | Bending vibration of HCC and HCH |
| 1427 vs | Bending vibration of HCH |
| 1456 s | Bending vibration of HCH |
| 1493 s | Bending vibration of HCC and HCH |
| 1664 s | Stretching vibration of C=C and bending vibration of HCC and HCH |
|
| Magnesium stearate (MgSt) |
| 890 m | Stretching vibration of C-C=O |
| 946 m | Stretching vibration of C-C |
| 1061 vs | Stretching vibration of O-C and C-C |
| 1100 m | Stretching vibration of C-C |
| 1127 s | Stretching vibration of C-C=O and C-C-O |
| 1174 m | Stretching vibration of C-C=O and CCO |
| 1300 vs | Out-of-plane rocking vibration of OCCC |
| 1370 m | Out-of-plane rocking vibration of OCCC |
| 1440 vs | Deformation vibration of H-C-H |
| 1460 s | Deformation vibration of H-C-H |
|
