Low-Content Quantitation in Entecavir Tablets Using 1064 nm Raman Spectroscopy

Table 3

Performance of the regression models using raw Raman data of calibration set samples and validation set samples which were obtained by randomly divided the calibration samples.

Preprocessing	Region	LV	RMSECV	R^2	RMSEC	RMSEP
Raw data	Full	2	0.14	0.896	0.09	0.28
	1350–1700 cm^−1	3	0.13	0.925	0.08	0.30
Baseline	Full	3	0.14	0.877	0.10	0.25
	1350–1700 cm^−1	3	0.15	0.941	0.07	0.28
MSC	Full	3	0.16	0.896	0.09	0.28
	1350–1700 cm^−1	4	0.14	0.925	0.08	0.30
SNV	Full	3	0.13	0.938	0.07	0.26
	1350–1700 cm^−1	2	0.13	0.962	0.06	0.10
Baseline + MSC	Full	2	0.14	0.896	0.09	0.28
	1350–1700 cm^−1	2	0.15	0.925	0.08	0.30
Baseline + SNV	Full	3	0.14	0.905	0.09	0.20
	1350–1700 cm^−1	3	0.13	0.970	0.05	0.05
Baseline + D1 data	Full	2	0.25	0.797	0.12	0.33
	1350–1700 cm^−1	3	0.13	0.892	0.09	0.25
Baseline + D2 data	Full	3	0.16	0.839	0.11	0.27
	1350–1700 cm^−1	4	0.18	0.899	0.09	0.31