Chemometrics-Enabled Raman Spectrometric Qualitative Determination and Assessment of Biochemical Alterations during Early Prostate Cancer Proliferation in Model Tissue

Table 4

Student’s t-test ( values) and effect sizes (Cohen’s d and Pearson’s correlation coefficients (r)) showing the relationship between the principal component scores of normal (PNT1a) and malignant (PC3) cells.

PC	Stage 1			Stage 2			Stage 3
	value	Cohen’s d	r	value	Cohen’s d	r	value	Cohen’s d	r
1	0.003	1.22	0.52	0.04	1.32	0.55	0.44	2.27	0.75
2	4.04 × 10^−19	0.99	0.44	2.11 × 10^−39	1.18	0.51	3.56 × 10^−39	2.36	0.76
3	0.0095	0.39	0.19	9.98 × 10^−10	0.99	0.44	0.029	0.18	0.09
4	7.13 × 10^−18	1.17	0.50	0.42	0.33	0.02	1.51 × 10^−18	1.38	0.57
5	3.24 × 10^−10	1.08	0.48	0.20	0.13	0.06	0.0088	0.34	0.17
6	0.18	0.15	0.07	0.32	0.08	0.04	0.0082	0.19	0.09
7	0.21	0.13	0.06	0.36	0.06	0.03	0.413	0.03	0.02
8	0.09	0.21	0.11	0.03	0.29	0.14	0.02	0.03	0.01
9	0.20	0.14	0.07	0.23	0.41	0.20	0.46	0.02	0.01
10	0.11	0.19	0.09	0.33	0.07	0.04	0.44	0.02	0.01