Table of Contents
Journal of Signal Transduction
Volume 2011 (2011), Article ID 834948, 12 pages
Research Article

Raf-1 Activation Prevents Caspase 9 Processing Downstream of Apoptosome Formation

Institute of Developmental Biology and Cancer, CNRS UMR6543, A. Lacassagne Center, University of Nice Sophia-Antipolis, 33 Avenue Valombrose, 06189 Nice, France

Received 30 July 2010; Revised 16 September 2010; Accepted 21 September 2010

Academic Editor: Alakananda Basu

Copyright © 2011 Sébastien Cagnol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

S1: Raf-1 activation prevents caspase 9 cleavage upon cytochrome c electroporation.

S2: Caspase 9 recruitment in the apoptosome following activation of cell extracts with cytochrome c and ATP is prevented by Raf activation.

S3: Raf-1 “kinase-dead” does not activate MAPK nor prevents caspase 9 cleavage.

  1. Supplementary Figure 1
  2. Supplementary Figure 2
  3. Supplementary Figure 3