Table of Contents
Journal of Signal Transduction
Volume 2012, Article ID 329635, 17 pages
http://dx.doi.org/10.1155/2012/329635
Review Article

Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

1Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy
2Department of Biochemistry, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland

Received 9 June 2011; Accepted 25 August 2011

Academic Editor: Saverio Francesco Retta

Copyright © 2012 Saverio Marchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [246 citations]

The following is the list of published articles that have cited the current article.

  • Luis A. Gómez, and Tory M. Hagen, “Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?,” Seminars in Cell & Developmental Biology, vol. 23, no. 7, pp. 758–767, 2012. View at Publisher · View at Google Scholar
  • Carla Ferreri, and Chryssostomos Chatgilialoglu, “Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools,” Expert Review Of Molecular Diagnostics, vol. 12, no. 7, pp. 767–780, 2012. View at Publisher · View at Google Scholar
  • Irena Szumiel, “Radiation hormesis: Autophagy and other cellular mechanisms,” International Journal of Radiation Biology, vol. 88, no. 9, pp. 619–628, 2012. View at Publisher · View at Google Scholar
  • Kristina Leuner, Kathrin Schulz, Tanja Schütt, Johannes Pantel, David Prvulovic, Virginie Rhein, Egemen Savaskan, Christian Czech, Anne Eckert, and Walter E. Müller, “Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes,” Molecular Neurobiology, vol. 46, no. 1, pp. 194–204, 2012. View at Publisher · View at Google Scholar
  • Kristina Leuner, Walter E. Müller, and Andreas S. Reichert, “From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease,” Molecular Neurobiology, vol. 46, no. 1, pp. 186–193, 2012. View at Publisher · View at Google Scholar
  • Carlotta Giorgi, Federica Baldassari, Angela Bononi, Massimo Bonora, Elena De Marchi, Saverio Marchi, Sonia Missiroli, Simone Patergnani, Alessandro Rimessi, Jan M. Suski, Mariusz R. Wieckowski, and Paolo Pinton, “Mitochondrial Ca2+ and apoptosis,” Cell Calcium, vol. 52, no. 1, pp. 36–43, 2012. View at Publisher · View at Google Scholar
  • Dae-Hyoun Lim, Jiyoung Jang, Seungjae Kim, Taegyeong Kang, Kangtaek Lee, and In-Hong Choi, “The effects of sub-lethal concentrations of silver nanoparticles on inflammatory and stress genes in human macrophages using cDNA microarray analysis,” Biomaterials, vol. 33, no. 18, pp. 4690–4699, 2012. View at Publisher · View at Google Scholar
  • S. Bayod, J. del Valle, J. F. Lalanza, S. Sanchez-Roige, B. de Luxan-Delgado, A. Coto-Montes, A. M. Canudas, A. Camins, R. M. Escorihuela, and M. Pallas, “Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues,” Experimental Gerontology, vol. 47, no. 12, pp. 925–935, 2012. View at Publisher · View at Google Scholar
  • Martin Pelletier, Talya S. Lepow, Leah K. Billingham, Michael P. Murphy, and Richard M. Siegel, “New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation,” Seminars in Immunology, vol. 24, no. 6, pp. 384–392, 2012. View at Publisher · View at Google Scholar
  • Luciane de Souza, Soraya S. Smaili, Rodrigo P. Ureshino, Rita Sinigaglia-Coimbra, Monica L. Andersen, Guiomar S. Lopes, and Sergio Tufik, “Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 39, no. 1, pp. 23–30, 2012. View at Publisher · View at Google Scholar
  • Karine Nouette-Gaulain, Xavier Capdevila, and Rodrigue Rossignol, “Local anesthetic ‘in-situ’ toxicity during peripheral nerve blocks,” Current Opinion in Anaesthesiology, vol. 25, no. 5, pp. 589–595, 2012. View at Publisher · View at Google Scholar
  • Jia Kang, and Shazib Pervaiz, “Mitochondria: Redox Metabolism and Dysfunction,” Biochemistry Research International, vol. 2012, pp. 1–14, 2012. View at Publisher · View at Google Scholar
  • Sameera Kongara, and Vassiliki Karantza, “The interplay between autophagy and ROS in tumorigenesis.,” Frontiers in oncology, vol. 2, pp. 171, 2012. View at Publisher · View at Google Scholar
  • Nicole Shangming Hou, and Stefan Taubert, “Function and regulation of lipid biology in Caenorhabditis elegans aging,” Frontiers In Physiology, vol. 3, 2012. View at Publisher · View at Google Scholar
  • Alexey Shapiguzov, Julia P. Vainonen, Michael Wrzaczek, and Jaakko Kangasjarvi, “ROS-talk - how the apoplast, the chloroplast, and the nucleus get the message through,” Frontiers in Plant Science, vol. 3, 2012. View at Publisher · View at Google Scholar
  • Upasana Sarangi, Khande Rao Paithankar, Jonnala Ujwal Kumar, Vaidyanathan Subramaniam, and Amere Subbarao Sreedhar, “17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.,” Drug target insights, vol. 6, pp. 19–39, 2012. View at Publisher · View at Google Scholar
  • Simone Patergnani, Saverio Marchi, Alessandro Rimessi, Massimo Bonora, Carlotta Giorgi, Kamal D. Mehta, and Paolo Pinton, “PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy,” Autophagy, vol. 9, no. 9, pp. 1367–1385, 2013. View at Publisher · View at Google Scholar
  • Alaa El-Din A. Bekhit, David L. Hopkins, Fahri T. Fahri, and Eric N. Ponnampalam, “Oxidative Processes in Muscle Systems and Fresh Meat: Sources, Markers, and Remedies,” Comprehensive Reviews in Food Science and Food Safety, vol. 12, no. 5, pp. 565–597, 2013. View at Publisher · View at Google Scholar
  • Erica J. Graham, and Frederick R. Adler, “Long-term models of oxidative stress and mitochondrial damage in insulin resistance progression,” Journal of Theoretical Biology, 2013. View at Publisher · View at Google Scholar
  • Bertram Daum, Andreas Walter, Angelika Horst, Heinz D. Osiewacz, and Werner Kuehlbrandt, “Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria,” Proceedings of The National Academy of Sciences of The United States of Ame, vol. 110, no. 38, pp. 15301–15306, 2013. View at Publisher · View at Google Scholar
  • Somayyeh Karami-Mohajeri, and Mohammad Abdollahi, “Mitochondrial dysfunction and organophosphorus compounds,” Toxicology and Applied Pharmacology, vol. 270, no. 1, pp. 39–44, 2013. View at Publisher · View at Google Scholar
  • Faten Shaeib, Jashoman Banerjee, Dhiman Maitra, Michael P. Diamond, and Husam M. Abu-Soud, “Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality,” Free Radical Biology and Medicine, vol. 58, pp. 154–159, 2013. View at Publisher · View at Google Scholar
  • Amalia M. Dolga, Michael F. Netter, Fabiana Perocchi, Nunzianna Doti, Lilja Meissner, Svenja Tobaben, Julia Grohm, Hans Zischka, Nikolaus Plesnila, Niels Decher, and Carsten Culmsee, “Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction,” Journal Of Biological Chemistry, vol. 288, no. 15, pp. 10792–10804, 2013. View at Publisher · View at Google Scholar
  • Syed A. Morshed, Risheng Ma, Rauf Latif, and Terry E. Davies, “How one TSH receptor antibody induces thyrocyte proliferation while another induces apoptosis,” Journal of Autoimmunity, vol. 47, pp. 17–24, 2013. View at Publisher · View at Google Scholar
  • Yougen Luo, Xifei Yang, Shenting Zhao, Churong Wei, Yedong Yin, Ting Liu, Sainv Jiang, Jiajun Xie, Xiaomei Wan, Muhua Mao, and Jiyun Wu, “Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons,” Neurochemistry International, vol. 63, no. 8, pp. 826–831, 2013. View at Publisher · View at Google Scholar
  • Rebeca Acin-Perez, and Jose A. Enriquez, “The Function of the Respiratory Supercomplexes: The plasticity model,” Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2013. View at Publisher · View at Google Scholar
  • Emanuele Calabro, Salvatore Condello, Monica Curro, Nadia Ferlazzo, Daniela Caccamo, Salvatore Magazu, and Riccardo Ientile, “Effects of Low Intensity Static Magnetic Field on FTIR Spectra and ROS Production in SH-SY5Y Neuronal-Like Cells,” Bioelectromagnetics, vol. 34, no. 8, pp. 618–629, 2013. View at Publisher · View at Google Scholar
  • Ling Tao, Sarah C. Forester, and Joshua D. Lambert, “The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells,” Molecular Nutrition & Food Research, vol. 58, no. 4, pp. 665–676, 2013. View at Publisher · View at Google Scholar
  • Saverio Marchi, Simone Patergnani, and Paolo Pinton, “The endoplasmic reticulum-mitochondria connection: One touch, multiple functions,” Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2013. View at Publisher · View at Google Scholar
  • Anil K. Mantha, Bibekananda Sarkar, and Gianluca Tell, “A Short Review on the Implications of Base Excision Repair Pathway for Neurons: Relevance to Neurodegenerative Diseases,” Mitochondrion, 2013. View at Publisher · View at Google Scholar
  • Hongjuan Yu, Wardit Tigchelaar, Debby P. Y. Koonen, Hemal H. Patel, Rudolf A. de Boer, Wiek H. van Gilst, B. Daan Westenbrink, and Herman H. W. Sillje, “AKIP1 Expression Modulates Mitochondrial Function in Rat Neonatal Cardiomyocytes,” Plos One, vol. 8, no. 11, 2013. View at Publisher · View at Google Scholar
  • Alessandro Rimessi, Massimo Bonora, Saverio Marchi, Simone Patergnani, Carlo M. T. Marobbio, Francesco M. Lasorsa, and Paolo Pinton, “Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction,” Autophagy, vol. 9, no. 11, pp. 1677–1686, 2013. View at Publisher · View at Google Scholar
  • Roland F. Hoffmann, Sina Zarrintan, Simone M. Brandenburg, Arjan Kol, Harold G. de Bruin, Shabnam Jafari, Freark Dijk, Dharamdajal Kalicharan, Marco Kelders, Harry R. Gosker, Nick H. T. ten Hacken, Johannes J. van der Want, Antoon J. M. van Oosterhout, and Irene H. Heijink, “Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells,” Respiratory Research, vol. 14, 2013. View at Publisher · View at Google Scholar
  • Jyotsna Mishra, and Sarman Singh, “Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death,” Experimental Parasitology, vol. 135, no. 2, pp. 397–406, 2013. View at Publisher · View at Google Scholar
  • Wim Van den Ende, and Sara K. El-Esawe, “Sucrose signaling pathways leading to fructan and anthocyanin accumulation: A dual function in abiotic and biotic stress responses?,” Environmental and Experimental Botany, 2013. View at Publisher · View at Google Scholar
  • Franklin Rosenfeldt, Mark Wilson, Geraldine Lee, Christina Kure, Ruchong Ou, Lesley Braun, and Judy de Haan, “Oxidative stress in surgery in an ageing population: Pathophysiology and therapy,” Experimental Gerontology, vol. 48, no. 1, pp. 45–54, 2013. View at Publisher · View at Google Scholar
  • T. Liu, S. E. Roh, J. A. Woo, H. Ryu, and D. E. Kang, “Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis,” Cell Death & Disease, vol. 4, 2013. View at Publisher · View at Google Scholar
  • P. A. Voziyan, A. V. Ivanova, E. M. Yazlovitskaya, R. Uzhachenko, and W. G. Yarbrough, “A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1,” Cell Death & Disease, vol. 4, 2013. View at Publisher · View at Google Scholar
  • Junyu Zhang, Qiong Wu, Shaowu Li, Xiaoyun Lu, Ji-Song Guan, Jin-Chun Chen, Yongxi Zhao, Guo-Qiang Chen, and Qian Cao, “3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism,” Biomaterials, vol. 34, no. 30, pp. 7552–7562, 2013. View at Publisher · View at Google Scholar
  • Hristina Ivanova, Ludwig Missiaen, Tim Vervliet, Jean-Paul Decuypere, Humbert De Smedt, Santeri Kiviluoto, Jan B. Parys, and Geert Bultynck, “Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress,” Biochimica Et Biophysica Acta-Molecular Cell Research, vol. 1833, no. 7, pp. 1612–1624, 2013. View at Publisher · View at Google Scholar
  • Ka Wing Cheng, Nengtai Ouyang, Chi C. Wong, Ninche Alston, Gerardo G. Mackenzie, Liqun Huang, Timothy Wiedmann, Basil Rigas, and Gang Xie, “Aerosol Administration of Phospho-Sulindac Inhibits Lung Tumorigenesis,” Molecular Cancer Therapeutics, vol. 12, no. 8, pp. 1417–1428, 2013. View at Publisher · View at Google Scholar
  • Shashi Bhushan, Suresh Kumar, Jeanne Yonkeu Ngogang, Santosh Kumar Guru, Ajit Kumar Saxena, Constant Anatole Pieme, Pantaleon Ambassa, and Bathelemy Ngameni, “Induction of mitochondrial dependent apoptosis and cell cycle arrest in human promyelocytic leukemia HL-60 cells by an extract from Dorstenia psilurus: a spice from Cameroon,” Bmc Complementary And Alternative Medicine, vol. 13, 2013. View at Publisher · View at Google Scholar
  • Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li, and Xiao-Feng Zhu, “Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production,” Journal of Translational Medicine, vol. 11, no. 1, pp. 32, 2013. View at Publisher · View at Google Scholar
  • Alessandro Rimessi, Simone Patergnani, Elli Ioannidi, and Paolo Pinton, “Chemoresistance and cancer-related inflammation: Two hallmarks of cancer connected by an atypical link, PKCζ,” Frontiers in Oncology, vol. 3, 2013. View at Publisher · View at Google Scholar
  • Eriberto Bressan, Letizia Ferroni, Chiara Gardin, Chiara Rigo, Michele Stocchero, Vincenzo Vindigni, Warren Cairns, and Barbara Zavan, “Silver Nanoparticles and Mitochondrial Interaction,” International Journal of Dentistry, vol. 2013, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  • O. Lorenzo, E. Ramírez, B. Picatoste, J. Egido, and J. Tuñón, “Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy,” Mediators of Inflammation, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Elena De Marchi, Federica Baldassari, Angela Bononi, Mariusz R. Wieckowski, and Paolo Pinton, “Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Haizhen Mo, Ying Chen, Liyong Huang, Hao Zhang, Juxiang Li, and Wenke Zhou, “Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Seong Eon Ryu, “Reactive Oxygen Species and Cellular Function Switch,” Hanyang Medical Reviews, vol. 33, no. 2, pp. 104, 2013. View at Publisher · View at Google Scholar
  • Ilaria Tocco, Ivan Munivrana, Chiara Rigo, Vincenzo Vindigni, Bruno Azzena, Marco Roman, Chiara Gardin, Warren R. L. Cairns, Carlo Barbante, Barbara Zavan, and Letizia Ferroni, “Active Silver Nanoparticles for Wound Healing,” International Journal Of Molecular Sciences, vol. 14, no. 3, pp. 4817–4840, 2013. View at Publisher · View at Google Scholar
  • Xiaofei Yan, FenLi Liang, Dongmin Li, and Jin Zheng, “Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway,” Molecular and Cellular Biochemistry, 2014. View at Publisher · View at Google Scholar
  • Huajun Jin, Arthi Kanthasamy, Anamitra Ghosh, Vellareddy Anantharam, Balaraman Kalyanaraman, and Anumantha G. Kanthasamy, “Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1842, no. 8, pp. 1282–1294, 2014. View at Publisher · View at Google Scholar
  • Lei Yang, Xuping Wang, and Xiaolan Yang, “Possible Antioxidant Mechanism of Melanoidins Extract from Shanxi Aged Vinegar in Mitophagy-Dependent and Mitophagy-Independent Pathways,” Journal of Agricultural and Food Chemistry, pp. 140814150817002, 2014. View at Publisher · View at Google Scholar
  • Giampaolo Morciano, Carlotta Giorgi, Massimo Bonora, Silvia Punzetti, Rita Pavasini, Mariusz R. Wieckowski, Gianluca Campo, and Paolo Pinton, “Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury,” Journal of Molecular and Cellular Cardiology, 2014. View at Publisher · View at Google Scholar
  • Ok Ja Yoon, Chang Yong Jung, Il Yung Sohn, Young Min Son, Byeong-Ung Hwang, Il Jin Kim, and Nae-Eung Lee, “Reduction in oxidative stress during cellular responses to chemically functionalised graphene,” Journal of Materials Chemistry B, vol. 2, no. 32, pp. 5202, 2014. View at Publisher · View at Google Scholar
  • Wenmin Huang, Dunhai Li, and Yongding Liu, “Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis,” Journal of Environmental Sciences, 2014. View at Publisher · View at Google Scholar
  • Arthur Wang, Åsa V. Keita, Van Phan, Catherine M. McKay, Ida Schoultz, Joshua Lee, Michael P. Murphy, Maria Fernando, Natalie Ronaghan, Dale Balce, Robin Yates, Michael Dicay, Paul L. Beck, Wallace K. MacNaughton, Johan D. Söderholm, and Derek M. McKay, “Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis,” The American Journal of Pathology, 2014. View at Publisher · View at Google Scholar
  • Xing Xu, Gaihong Wang, Tingting Zhou, Lili Chen, Jing Chen, and Xu Shen, “Novel approaches to drug discovery for the treatment of type 2 diabetes,” Expert Opinion on Drug Discovery, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • Salwa Fares Ahmed, “The possible protective effect of vitamin C on the kidney cortex of adult female albino rat after chronic exposure to malathion,” The Egyptian Journal of Histology, vol. 37, no. 2, pp. 402–416, 2014. View at Publisher · View at Google Scholar
  • Geng Tian, Jinko Sawashita, Hiroshi Kubo, Shin-ya Nishio, Shigenari Hashimoto, Nobuyoshi Suzuki, Hidekane Yoshimura, Mineko Tsuruoka, Yaoyong Wang, Yingye Liu, Hongming Luo, Zhe Xu, Masayuki Mori, Mitsuaki Kitano, Kazunori Hosoe, Toshio Takeda, Shin-ichi Usami, and Keiichi Higuchi, “Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice,” Antioxidants & Redox Signaling, vol. 20, no. 16, pp. 2606–2620, 2014. View at Publisher · View at Google Scholar
  • Sabzali Javadov, Sehwan Jang, and Bryan Agostini, “Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives,” Pharmacology & Therapeutics, 2014. View at Publisher · View at Google Scholar
  • D. Otali, R. J. Novak, W. Wan, S. Bu, D. R. Moellering, and M. De Luca, “Increased production of mitochondrial reactive oxygen species and reduced adult life span in an insecticide-resistant strain of Anopheles gambiae,” Bulletin of Entomological Research, vol. 104, no. 3, pp. 323–333, 2014. View at Publisher · View at Google Scholar
  • Qian Yang, Lei Shi, Kunlun Huang, and Wentao Xu, “Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK-293),” Food and Chemical Toxicology, 2014. View at Publisher · View at Google Scholar
  • Junfang Wu, Jie Niu, Xiaopeng Li, Xianwei Wang, Zhikun Guo, and Fenxi Zhang, “TGF-beta 1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production,” Bmc Developmental Biology, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Ivan O. Rosas, Paul F. Dellaripa, David J. Lederer, Dinesh Khanna, Lisa R. Young, and Fernando J. Martinez, “Interstitial Lung Disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases,” Annals of the American Thoracic Society, vol. 11, no. Supplement3, pp. S169–S177, 2014. View at Publisher · View at Google Scholar
  • S. Karami-Mohajeri, M. R. Hadian, S. Fouladdel, E. Azizi, M. H. Ghahramani, R. Hosseini, and M. Abdollahi, “Mechanisms of muscular electrophysiological and mitochondrial dysfunction following exposure to malathion, an organophosphorus pesticide,” Human & Experimental Toxicology, vol. 33, no. 3, pp. 251–263, 2014. View at Publisher · View at Google Scholar
  • M Bonora, E De Marchi, S Patergnani, J M Suski, F Celsi, A Bononi, C Giorgi, S Marchi, A Rimessi, J Duszyński, T Pozzan, M R Wieckowski, and P Pinton, “Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process,” Cell Death and Differentiation, 2014. View at Publisher · View at Google Scholar
  • Christian Frezza, “The role of mitochondria in the oncogenic signal transduction,” International Journal of Biochemistry & Cell Biology, vol. 48, pp. 11–17, 2014. View at Publisher · View at Google Scholar
  • Ha-Na Jung, Tamanna Zerin, Biswajit Podder, Ho-Yeon Song, and Yong-Sik Kim, “Cytotoxicity and gene expression profiling of polyhexamethylene guanidine hydrochloride in human alveolar A549 cells,” Toxicology in Vitro, 2014. View at Publisher · View at Google Scholar
  • Yung-Chia Chen, Ling-Hui Chien, Bu-Miin Huang, and Yi-Chen Chia, “Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells,” Journal of Functional Foods, 2014. View at Publisher · View at Google Scholar
  • Roman Uzhachenko, Sergey V. Ivanov, Wendell G. Yarbrough, Anil Shanker, Ruslan Medzhitov, and Alla V. Ivanova, “ Fus1/Tusc2 Is a Novel Regulator of Mitochondrial Calcium Handling, Ca 2+ -Coupled Mitochondrial Processes, and Ca 2+ -Dependent NFAT and NF-κB Pathways in CD4 + T Cells ,” Antioxidants & Redox Signaling, pp. 140204083737003, 2014. View at Publisher · View at Google Scholar
  • Jiong Meng, Tao Chi, Ying Guo, Xinyan Peng, Yujun Jiang, Chaoxin Man, Peng Liu, and Shaomin Liu, “Lactobacillus plantarum NDC 75017 alleviates the learning and memory ability in aging rats by reducing mitochondrial dysfunction,” Experimental and Therapeutic Medicine, vol. 8, no. 6, pp. 1841–1846, 2014. View at Publisher · View at Google Scholar
  • Cheng-Chang Yeh, Jenny Zwei-Chieng Chang, Wan-Hsien Yang, Hao-Hueng Chang, Eddie Hsiang-Hua Lai, and Mark Yen-Ping Kuo, “NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells,” Clinical Oral Investigations, 2014. View at Publisher · View at Google Scholar
  • Amit Singhal, Liu Jie, Pavanish Kumar, Gan Suay Hong, Melvin Khee-Shing Leow, Bhairav Paleja, Liana Tsenova, Natalia Kurepina, Jinmiao Chen, Francesca Zolezzi, Barry Kreiswirth, Michael Poidinger, Cynthia Chee, Gilla Kaplan, Yee Tang Wang, and Gennaro De Libero, “Metformin as adjunct antituberculosis therapy,” Science Translational Medicine, vol. 6, no. 263, 2014. View at Publisher · View at Google Scholar
  • Saverio Marchi, Carlotta Giorgi, Monika Oparka, Jerzy Duszynski, Mariusz R Wieckowski, and Paolo Pinton, “Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes (MAM),” Molecular & Cellular Oncology, pp. 00–00, 2014. View at Publisher · View at Google Scholar
  • Seung Koo Lee, Luke J. Mortensen, Charles P. Lin, and Ching-Hsuan Tung, “An authentic imaging probe to track cell fate from beginning to end,” Nature Communications, vol. 5, pp. 5216, 2014. View at Publisher · View at Google Scholar
  • Ling Yu, Li Xia Gao, Xiao Qing Ma, Fang Xin Hu, Chang Ming Li, and Zhisong Lu, “ Involvement of superoxide and nitric oxide in BRAF V600E inhibitor PLX4032-induced growth inhibition of melanoma cells ,” Integr. Biol., vol. 6, no. 12, pp. 1211–1217, 2014. View at Publisher · View at Google Scholar
  • Alice Accorsi, Federica Boraldi, Enzo Ottaviani, and Daniela Quaglinopp. 105–124, 2014. View at Publisher · View at Google Scholar
  • Christian Frezza, “The role of mitochondria in the oncogenic signal transduction,” The International Journal of Biochemistry & Cell Biology, 2014. View at Publisher · View at Google Scholar
  • Vitor Teixeira, Tânia C Medeiros, Rita Vilaça, Pedro Moradas-Ferreira, and Vítor Costa, “Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.,” Microbial cell (Graz, Austria), vol. 1, no. 1, pp. 21–36, 2014. View at Publisher · View at Google Scholar
  • Jian Lu, Tao Wang, Chang-Lai Zhu, Yi Shen, Hui-Yin Qian, Li-Jun Liu, Bao-Chun Zhou, Yan Xiao, Jin-Ning Mao, Guo-Yin An, and Ming-Zhong Rui, “Effects of mild hypothermia on the ROS and expression of caspase-3 mRNA and LC3 of hippocampus nerve cells in rats after cardiopulmonary resuscitation.,” World journal of emergency medicine, vol. 5, no. 4, pp. 298–305, 2014. View at Publisher · View at Google Scholar
  • Joanna Rybka, Kornelia Kedziora-Kornatowska, Floor van Heesch, and Jozef Kedziora, “Late-Life Depression and Antioxidant Supplements,” Aging, pp. 167–176, 2014. View at Publisher · View at Google Scholar
  • Wei-Zhe Liang, Pei-Feng Liu, Earl Fu, Hao-Sheng Chung, Chung-Ren Jan, Chih-Hsuan Wu, Chih-Wen Shu, and Yao-Dung Hsieh, “Selective cytotoxic effects of low-power laser irradiation on human oral cancer cells,” Lasers in Surgery and Medicine, 2015. View at Publisher · View at Google Scholar
  • Edward Baker, and Geraldine Lee, “The science of reperfusion injury post cardiac arrest – Implications for emergency nurses,” International Emergency Nursing, 2015. View at Publisher · View at Google Scholar
  • Claire A. Chougnet, Robert I. Thacker, Hesham M. Shehata, Cassandra M. Hennies, Maria A. Lehn, Celine S. Lages, and Edith M. Janssen, “Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction,” Journal Of Immunology, vol. 195, no. 6, pp. 2624–2632, 2015. View at Publisher · View at Google Scholar
  • Kwanghyun Lee, Jae Eun Jeong, In Hwang Kim, Kun-Soo Kim, and Bong-Gun Ju, “ Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen species ,” Journal of Cellular and Molecular Medicine, vol. 19, no. 12, pp. 2851–2864, 2015. View at Publisher · View at Google Scholar
  • S. A. Morshed, and T. F. Davies, “Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies,” Hormone And Metabolic Research, vol. 47, no. 10, pp. 727–734, 2015. View at Publisher · View at Google Scholar
  • Likun Ren, Zhuqing Wang, Lei An, Zhennan Zhang, Kun Tan, Kai Miao, Li Tao, Linghua Cheng, Zhenni Zhang, Mingyao Yang, Zhonghong Wu, and Jianhui Tian, “ Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos ,” Human Reproduction, pp. dev228, 2015. View at Publisher · View at Google Scholar
  • Bola Sadashiva Satish Rao, Mandala Rayabandla Sunil Kumar, Shubhankar Das, Kiran Aithal, and Nayanabhirama Udupa, “Radiosensitizing potential of Plumbagin in B16F1 melanoma tumor cells through mitochondrial mediated programmed cell death,” Journal of Applied Biomedicine, 2015. View at Publisher · View at Google Scholar
  • Hassan Chaachouay, Birgit Fehrenbacher, Mahmoud Toulany, Martin Schaller, Gabriele Multhoff, and H. Peter Rodemann, “AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro,” Radiotherapy and Oncology, 2015. View at Publisher · View at Google Scholar
  • Dan-Bi Kim, Gi-Hae Shin, Jae-Min Kim, Young-Hyun Kim, Jin-Ha Lee, Jong Seok Lee, Hye-Jin Song, Soo Young Choe, In-Jae Park, Ju-Hyun Cho, and Ok-Hawn Lee, “Antioxidant and anti-ageing activities of citrus-based juice mixture,” Food Chemistry, 2015. View at Publisher · View at Google Scholar
  • Gurugirijha Rathnasamy, Madhuvika Murugan, Eng-Ang Ling, and Charanjit Kaur, “Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress,” Molecular Neurobiology, 2015. View at Publisher · View at Google Scholar
  • Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, and Yue-min Ding, “Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia,” Journal Of Zhejiang University-Science B, vol. 16, no. 7, pp. 593–601, 2015. View at Publisher · View at Google Scholar
  • Seung-Hyun Ro, Ian Semple, Allison Ho, Hwan-Woo Park, and Jun Hee Lee, “Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue,” Frontiers in Endocrinology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Karan Singh Chahal, Atish Prakash, and Abu Bakar Abdul Majeed, “The role of multifunctional drug therapy against carbamate induced neuronal toxicity during acute and chronic phase in rats,” Environmental Toxicology and Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Da Hee Lee, Yoon Jeong Nam, and Chung Soo Lee, “Apocynin attenuates cholesterol oxidation product-induced programmed cell death by suppressing NF-κB-mediated cell death process in differentiated PC12 cells,” Neurochemistry International, 2015. View at Publisher · View at Google Scholar
  • Ching-Fen Wu, and Thomas Efferth, “Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells,” Journal of Natural Products, pp. 150602092223003, 2015. View at Publisher · View at Google Scholar
  • Vašková Janka, Daniel Žatko, Vaško Ladislav, Perjési Pál, Poráčová Janka, and Mojžišová Gabriela, “Some ferrocenyl chalcones as useful candidates for cancer treatment,” In Vitro Cellular & Developmental Biology - Animal, 2015. View at Publisher · View at Google Scholar
  • Yoon Jeong Nam, Da Hee Lee, Min Sung Lee, and Chung Soo Lee, “Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-κB pathways,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 388, no. 9, pp. 921–930, 2015. View at Publisher · View at Google Scholar
  • Chunli Wu, Xiaoping Geng, Shengyun Wan, Hui Hou, Fanzong Yu, Benli Jia, and Lei Wang, “Cecropin-P17, an analog of Cecropin B, inhibits human hepatocellular carcinoma cell HepG-2 proliferation via regulation of ROS, Caspase, Bax, and Bcl-2,” Journal of Peptide Science, 2015. View at Publisher · View at Google Scholar
  • Da Hee Lee, Yoon Jeong Nam, and Chung Soo Lee, “Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells,” Naunyn-Schmiedeberg's Archives of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Orit Bar-Am, Tamar Amit, Moussa B. Youdim, and Orly Weinreb, “Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets,” Journal of Neural Transmission, 2015. View at Publisher · View at Google Scholar
  • Jian Wu, Yuefeng Sun, Yannan Zhao, Jian Zhang, Lilan Luo, Meng Li, Jinlong Wang, Hong Yu, Guifu Liu, Liusha Yang, Guosheng Xiong, Jian-Min Zhou, Jianru Zuo, Yonghong Wang, and Jiayang Li, “Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species,” Cell Research, 2015. View at Publisher · View at Google Scholar
  • Shengbiao Li, Jingyi Guo, Zhongfu Ying, Shen Chen, Liang Yang, Keshi Chen, Qi Long, Dajiang Qin, Duanqing Pei, and Xingguo Liu, “Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening dependent apoptotic sensitivity in an induced pluripotent stem cell model,” Hepatology, 2015. View at Publisher · View at Google Scholar
  • Alessandro Rimessi, Valentino Bezzerri, Simone Patergnani, Saverio Marchi, Giulio Cabrini, and Paolo Pinton, “Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis,” Nature Communications, vol. 6, pp. 6201, 2015. View at Publisher · View at Google Scholar
  • Daniel J. Lambert, Nigam Parikh, Stephen J. Messham, Giles Edwards, Hieu van Truong, Nicola M. Dempster, Michael G.B. Drew, Lutfun Nahar, Satyajit D. Sarker, and Fyaz M.D. Ismail, “One-pot synthesis and negative ion mass spectrometric investigation of a densely functionalized cinnoline,” Tetrahedron Letters, 2015. View at Publisher · View at Google Scholar
  • Alessandro Lana, and Lello Zolla, “Apoptosis or autophagy, that is the question: Two ways for muscle sacrifice towards meat,” Trends in Food Science & Technology, 2015. View at Publisher · View at Google Scholar
  • Samil Jung, Chengping Li, Jingjing Duan, Soonduck Lee, Kyeri Kim, Yeonji Park, Young Yang, Keun-Il Kim, Jong-Seok Lim, Chung-Il Cheon, Young-Sook Kang, and Myeong-Sok Lee, “TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition,” Oncotarget, vol. 6, no. 30, pp. 29060–29075, 2015. View at Publisher · View at Google Scholar
  • Sara Cogliati, Rebeca Acín-Pérez, and José Enriquez, “ATPases and Mitochondrial Supercomplexes,” Redox Proteins in Supercomplexes and Signalosomes, pp. 61–80, 2015. View at Publisher · View at Google Scholar
  • Lu Wang, Herbert M. Espinoza, James W. MacDonald, Theo K. Bammler, Chase R. Williams, Andrew Yeh, Ke’ale W. Louie, David J. Marcinek, and Evan P. Gallagher, “Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury,” Toxicological Sciences, pp. kfv223, 2015. View at Publisher · View at Google Scholar
  • Cara E. Brook, and Andrew P. Dobson, “Bats as ‘special’ reservoirs for emerging zoonotic pathogens,” Trends in Microbiology, 2015. View at Publisher · View at Google Scholar
  • Giampaolo Morciano, Carlotta Giorgi, Massimo Bonora, Silvia Punzetti, Rita Pavasini, Mariusz R. Wieckowski, Gianluca Campo, and Paolo Pinton, “Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury,” Journal Of Molecular And Cellular Cardiology, vol. 78, pp. 142–153, 2015. View at Publisher · View at Google Scholar
  • Eunjung Moon, Hye Min Park, Choong Hwan Lee, Seon-Gil Do, Jong-Moon Park, Na-Young Han, Moon Ho Do, Jong Ha Lee, Hookeun Lee, and Sun Yeou Kim, “Dihydrolipoyl dehydrogenase as a potential UVB target in skin epidermis; using an integrated approach of label-free quantitative proteomics and targeted metabolite analysis,” Journal of Proteomics, 2015. View at Publisher · View at Google Scholar
  • Alessandro Rimessi, Simone Patergnani, Massimo Bonora, Mariusz R. Wieckowski, and Paolo Pinton, “Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior,” Frontiers in Oncology, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Matteo Zanardelli, Laura Micheli, Raffaella Nicolai, Paola Failli, Carla Ghelardini, and Lorenzo Di Cesare Mannelli, “Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells,” International Journal Of Molecular Sciences, vol. 16, no. 3, pp. 5386–5399, 2015. View at Publisher · View at Google Scholar
  • Cary N. Weiss, and Keisuke Ito, “DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia,” International Journal Of Molecular Sciences, vol. 16, no. 3, pp. 6183–6201, 2015. View at Publisher · View at Google Scholar
  • Rachana Singh, Samiksha Singh, Parul Parihar, Rohit K. Mishra, Durgesh K. Tripathi, Vijay P. Singh, Devendra K. Chauhan, and Sheo M. Prasad, “Reactive Oxygen Species (ROS): Beneficial Companions of Plants’ Developmental Processes,” Frontiers in Plant Science, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Liangyan Shi, Jinjin Zhang, Zhiwen Lai, Yong Tian, Li Fang, Meng Wu, Jiaqiang Xiong, Xian Qin, Aiyue Luo, and Shixuan Wang, “Long-Term Moderate Oxidative Stress Decreased Ovarian Reproductive Function by Reducing Follicle Quality and Progesterone Production,” Plos One, vol. 11, no. 9, pp. e0162194, 2016. View at Publisher · View at Google Scholar
  • Nibedita Patel, Koteswara Rao Garikapati, M. Janaki Ramaiah, Kavi Kishor Polavarapu, Utpal Bhadra, and Manika Pal Bhadra, “miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1,” Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Xiao-Fei Zhang, Rong-qin Sun, Yi-fan Jia, Qing Chen, Rong-Fu Tu, Ke-ke Li, Xiao-Dong Zhang, Run-Lei Du, and Ri-hui Cao, “Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents,” Scientific Reports, vol. 6, no. 1, 2016. View at Publisher · View at Google Scholar
  • Shujiang Cheng, Regina Hourigan, Zeenat Nabi, and Laurence Du-Thumm, “Cellular Energy Metabolism and Oxidative Stress,” Textbook of Aging Skin, pp. 617–627, 2016. View at Publisher · View at Google Scholar
  • Marianna E. Jung, and Daniel B. Metzger, “A sex difference in oxidative stress and behavioral suppression induced by ethanol withdrawal in rats,” Behavioural Brain Research, 2016. View at Publisher · View at Google Scholar
  • Navneet Agnihotri, Gayatri Sharma, Isha Rani, Renuka, and Archana Bhatnagar, “Fish oil prevents colon cancer by modulation of structure and function of mitochondria,” Biomedicine & Pharmacotherapy, vol. 82, pp. 90–97, 2016. View at Publisher · View at Google Scholar
  • Prachi Gupta, Carolyn T. Jordan, Mihail I. Mitov, D. Allan Butterfield, J. Zach Hilt, and Thomas D. Dziubla, “Controlled Curcumin Release via Conjugation into PBAE Nanogels Enhances Mitochondrial Protection against Oxidative Stress,” International Journal of Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Kyung-Ho Kim, Seong-Jun Cho, Byung-Oh Kim, and Suhkneung Pyo, “Differential pro-apoptotic effect of allicin in oestrogen receptor-positive or -negative human breast cancer cells,” Journal of Functional Foods, vol. 25, pp. 341–353, 2016. View at Publisher · View at Google Scholar
  • Robert Esterberg, Tor Linbo, Sarah B. Pickett, Patricia Wu, Henry C. Ou, Edwin W. Rubel, and David W. Raible, “Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death,” Journal of Clinical Investigation, 2016. View at Publisher · View at Google Scholar
  • Yuexia Xie, Dejun Liu, Yan Zhou, Xianming Kong, Peifeng Liu, Chenlei Cai, Xiaojing Chen, Liangliang Wu, Yongwei Sun, and Huili Dai, “Size-dependent cytotoxicity of Fe3O4 nanoparticles induced by biphasic regulation of oxidative stress in different human hepatoma cells,” International Journal of Nanomedicine, vol. 11, pp. 3557–3570, 2016. View at Publisher · View at Google Scholar
  • Jui-Chih Chang, Shou-Jen Kuo, Shih-Li Su, Yu-Shan Cheng, Mingli Hsieh, Karl Johan Tronstad, Kuo-Chia Yan, Ching-Liang Hsieh, Wei-Yong Lin, Chin-San Liu, Shey-Lin Wu, Fredrik Hoel, Ko-Hung Liu, and August Hoel, “Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Danas Baniulis, S. Saif Hasan, Inga Miliute, and William A. Cramer, “Mechanisms of Superoxide Generation and Signaling in Cytochrome bc Complexes,” Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling, vol. 41, pp. 397–417, 2016. View at Publisher · View at Google Scholar
  • Anna Atlante, Maria Favia, Antonella Bobba, Lorenzo Guerra, Valeria Casavola, and Stephan Joel Reshkin, “Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function,” Journal Of Bioenergetics And Biomembranes, vol. 48, no. 3, pp. 197–210, 2016. View at Publisher · View at Google Scholar
  • Mahboobeh Pordeli, Maryam Nakhjiri, Maliheh Safavi, Sussan Kabudanian Ardestani, and Alireza Foroumadi, “Anticancer effects of synthetic hexahydrobenzo [g]chromen-4-one derivatives on human breast cancer cell lines,” Breast Cancer, 2016. View at Publisher · View at Google Scholar
  • Masakazu Ishikawa, Ikuko Yuyama, Hiroshi Shimizu, Masafumi Nozawa, Kazuho Ikeo, and Takashi Gojobori, “Different Endosymbiotic Interactions in Two Hydra Species Reflect the Evolutionary History of Endosymbiosis,” Genome Biology and Evolution, vol. 8, no. 7, pp. 2155–2163, 2016. View at Publisher · View at Google Scholar
  • Giampaolo Morciano, Gaia Pedriali, Luigi Sbano, Tommaso Iannitti, Carlotta Giorgi, and Paolo Pinton, “Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1,” Biology of the Cell, 2016. View at Publisher · View at Google Scholar
  • Alfred M. Sciuto, Benjamin J. Wong, Margaret E. Martens, Heidi Hoard-Fruchey, and Michael W. Perkins, “Phosphine toxicity: a story of disrupted mitochondrial metabolism,” Annals of the New York Academy of Sciences, 2016. View at Publisher · View at Google Scholar
  • Tom Sieprath, Tobias D. J. Corne, Peter H. G. M. Willems, Werner J. H. Koopman, and Winnok H. De Vos, “Integrated High-Content Quantification of Intracellular ROS Levels and Mitochondrial Morphofunction,” Focus on Bio-Image Informatics, vol. 219, pp. 149–177, 2016. View at Publisher · View at Google Scholar
  • Da Hee Lee, and Chung Soo Lee, “Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes,” European Journal of Pharmacology, 2016. View at Publisher · View at Google Scholar
  • X. Lin, and T. Huang, “Impact of pregnancy and oestrogen on psoriasis and potential therapeutic use of selective oestrogen receptor modulators for psoriasis,” Journal of the European Academy of Dermatology and Venereology, 2016. View at Publisher · View at Google Scholar
  • Arunava Bandyopadhaya, Caterina Constantinou, Nikolaos Psychogios, Ryusuke Ueki, Shingo Yasuhara, J. A. Jeevendra Martyn, Julie Wilhelmy, Michael Mindrinos, Laurence G. Rahme, and A. Aria Tzika, “Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle,” International Journal Of Molecular Medicine, vol. 37, no. 4, pp. 867–878, 2016. View at Publisher · View at Google Scholar
  • Diana Tamayo, Jose F. Munoz, Angela Lopez, Martha Uran, Juan Herrera, Clayton L. Borges, Angela Restrepo, Celia M. Soares, Carlos P. Taborda, Agostinho J. Almeida, Juan G. McEwen, and Orville Hernandez, “Identification and Analysis of the Role of Superoxide Dismutases Isoforms in the Pathogenesis of Paracoccidioides spp.,” Plos Neglected Tropical Diseases, vol. 10, no. 3, 2016. View at Publisher · View at Google Scholar
  • Wen-Jun Duan, Yi-Fang Li, Fang-Lan Liu, Jie Deng, Yan-Ping Wu, Wei-Lin Yuan, Bun Tsoi, Jun-Li Chen, Qi Wang, Shao-Hui Cai, Hiroshi Kurihara, and Rong-Rong He, “A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages,” Free Radical Biology and Medicine, 2016. View at Publisher · View at Google Scholar
  • Chunxia Chen, Jing Cao, Xiaoyan Ma, Xiaobo Wang, Qiuyun Chen, Shihai Yan, Ningwei Zhao, Zhirong Geng, and Zhilin Wang, “Neuroprotection by Polynitrogen Manganese Complexes: Regulation of Reactive Oxygen Species-Related Pathways,” Scientific Reports, vol. 6, pp. 20853, 2016. View at Publisher · View at Google Scholar
  • Shujiang Cheng, Regina Hourigan, Zeenat Nabi, and Laurence Du-Thumm, “Cellular Energy Metabolism and Oxidative Stress,” Textbook of Aging Skin, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • Carlotta Giorgi, Massimo Bonora, Sonia Missiroli, Claudia Morganti, Giampaolo Morciano, Mariusz R. Wieckowski, and Paolo Pinton, “Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants,” Frontiers in Oncology, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Loubna Boukhzar, Abdallah Hamieh, Dorthe Cartier, Yannick Tanguy, Ifat Alsharif, Matthieu Castex, Arnaud Arabo, Sana El Hajji, Jean-Jacques Bonnet, Mohammec Errami, Anthony Falluel Morel, Abdeslam Chagraoui, Isabelle Lihrmann, and Youssef Anouar, “Selenoprotein T Exerts an Essential Oxidoreductase Activity that Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease,” Antioxidants & Redox Signaling, 2016. View at Publisher · View at Google Scholar
  • Marie-Pierre Golinelli-Cohen, Ewen Lescop, C?cile Mons, Sergio Gon?alves, Martin Cl?mancey, J?r?me Santolini, Eric Guittet, Genevi?ve Blondin, Jean-Marc Latour, and C?cile Bouton, “Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster,” Journal of Biological Chemistry, vol. 291, no. 14, pp. 7583–7593, 2016. View at Publisher · View at Google Scholar
  • Dong-Ho Bak, Hyung Don Kim, Young Ock Kim, Chun Geun Park, Seung-Yun Han, and Jwa-Jin Kim, “Neuroprotective effects of 20(S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells,” International Journal Of Molecular Medicine, vol. 37, no. 2, pp. 378–386, 2016. View at Publisher · View at Google Scholar
  • Shin-Yu Tsai, Pei-Chin Chung, Eddy E. Owaga, I-Jong Tsai, Pei-Yuan Wang, Jeng-I Tsai, Tien-Shun Yeh, and Rong-Hong Hsieh, “Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis,” Nutrition & Metabolism, vol. 13, no. 1, 2016. View at Publisher · View at Google Scholar
  • Ching-Shu Lai, Jia-Ching Wu, Chi-Tang Ho, and Min-Hsiung Pan, “Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation,” Molecular Nutrition & Food Research, pp. 1600721, 2016. View at Publisher · View at Google Scholar
  • Alisha Khera, Jessica J. Vanderlelie, Olivia Holland, and Anthony V. Perkins, “Overexpression of Endogenous Anti-Oxidants with Selenium Supplementation Protects Trophoblast Cells from Reactive Oxygen Species-Induced Apoptosis in a Bcl-2-Dependent Manner,” Biological Trace Element Research, 2016. View at Publisher · View at Google Scholar
  • Dominika Truban, Xu Hou, Thomas R. Caulfield, Fabienne C. Fiesel, and Wolfdieter Springer, “PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?,” Journal of Parkinson's Disease, pp. 1–17, 2016. View at Publisher · View at Google Scholar
  • Xiaobo Li, Chengcheng Zhang, Xin Zhang, Shizhi Wang, Qingtao Meng, Shenshen Wu, Hongbao Yang, Yankai Xia, and Rui Chen, “An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles,” Particle and Fibre Toxicology, vol. 13, no. 1, 2016. View at Publisher · View at Google Scholar
  • Sandesh Chibber, Athanasios Alexiou, Mohammed Nabil Alama, George Emilio Barreto, Gjumrakch Aliev, and Ghulam Mohammad Ashraf, “A Synopsis on the Linkage Between Age-Related Dementias and Vascular Disorders,” Cns & Neurological Disorders-Drug Targets, vol. 15, no. 2, pp. 250–258, 2016. View at Publisher · View at Google Scholar
  • Ji-Young Hong, Kenjirou Hara, Jun-Woo Kim, Eisuke F. Sato, Eun Bo Shim, and Kwang-Hyun Cho, “Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin,” The Korean Journal of Physiology & Pharmacology, vol. 20, no. 4, pp. 367, 2016. View at Publisher · View at Google Scholar
  • Rajagopalan Geetha, Chandrasekaran Sathiya Priya, and Carani Venkatraman Anuradha, “Troxerutin abrogates mitochondrial oxidative stress and myocardial apoptosis in mice fed calorie-rich diet,” Chemico-Biological Interactions, 2017. View at Publisher · View at Google Scholar
  • Rodrigo Martins Pereira, Rania A. Mekary, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, José Rodrigo Pauli, and Leandro Pereira de Moura, “Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes,” Heart Failure Reviews, 2017. View at Publisher · View at Google Scholar
  • Aditi Jain, and Vibha Rani, “Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts,” Molecular and Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Xiang Li, Charalambos Michaeloudes, Yuelin Zhang, Coen H. Wiegman, Ian M. Adcock, Qizhou Lian, Judith C.W. Mak, Pankaj K. Bhavsar, and Kian Fan Chung, “Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways,” Journal of Allergy and Clinical Immunology, 2017. View at Publisher · View at Google Scholar
  • Sang Jun Han, Hong Seok Choi, Jee In Kim, Jeen-Woo Park, and Kwon Moo Park, “IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury,” Redox Biology, 2017. View at Publisher · View at Google Scholar
  • Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, and José Pedraza-Chaverri, “Medicinal properties of mangosteen ( Garcinia mangostana L.): A comprehensive update,” Food and Chemical Toxicology, 2017. View at Publisher · View at Google Scholar
  • Shanjun Tao, Younan Ren, Haowen Zheng, Mengqiu Zhao, Xu Zhang, Yuanmei Zhu, Jieren Yang, and Shuguo Zheng, “Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential,” European Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Natalie A. Duggett, Lisa A. Griffiths, and Sarah J.L. Flatters, “Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons,” Pain, vol. 158, no. 8, pp. 1499–1508, 2017. View at Publisher · View at Google Scholar
  • Susanne Schaefer, and Barbara Guerra, “Protein kinase CK2 regulates redox homeostasis through NF-?B and Bcl-xL in cardiomyoblasts,” Molecular and Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Shanel Dhani, Savania Nagiah, Dhaneshree B. Naidoo, and Anil A. Chuturgoon, “Fusaric Acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cells,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Etienne Hebert-Chatelain, Giovanni Marsicano, and Tifany Desprez, “Cannabinoids and Mitochondria,” Endocannabinoids and Lipid Mediators in Brain Functions, pp. 211–235, 2017. View at Publisher · View at Google Scholar
  • Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, and Koichi Wakabayashi, “Alteration of mitochondrial protein PDHA1 in Lewy body disease and PARK14,” Biochemical and Biophysical Research Communications, 2017. View at Publisher · View at Google Scholar
  • Imran Khan, and Sun Chul Kang, “ Apoptotic Activity of Lactobacillus plantarum DGK-17-Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS-JNK Signaling Pathway ,” Journal of Food Science, 2017. View at Publisher · View at Google Scholar
  • W. Wang, X. Qu, X. Dang, D. Shang, L. Yang, Y. Li, D. Xu, J. G. Martin, Q. Hamid, J. Liu, and Y. Chang, “Human β-defensin-3 induces IL-8 release and apoptosis in airway smooth muscle cells,” Clinical & Experimental Allergy, 2017. View at Publisher · View at Google Scholar
  • Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, and Saveria Aquila, “Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells,” Tumor Biology, vol. 39, no. 5, pp. 101042831770164, 2017. View at Publisher · View at Google Scholar
  • Ting Xia, Ying-Nan Wang, Chuan-Xin Zhou, Li-Mei Wu, Yong Liu, Qian-Hong Zeng, Xiang-Long Zhang, Jia-Hui Yao, Min Wang, and Jian-Pei Fang, “Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells,” Molecular Medicine Reports, vol. 15, no. 6, pp. 3591–3598, 2017. View at Publisher · View at Google Scholar
  • Sarah B. Ohlen, Magdalena L. Russell, Michael J. Brownstein, and Frances Lefcort, “BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia,” Proceedings of the National Academy of Sciences, vol. 114, no. 19, pp. 5035–5040, 2017. View at Publisher · View at Google Scholar
  • Ming-Yuan Xu, Pan Wang, Ying-Jian Sun, Lin Yang, and Yi-Jun Wu, “Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells,” Food and Chemical Toxicology, 2017. View at Publisher · View at Google Scholar
  • Stefanie Menges, Georgia Minakaki, Patrick M. Schaefer, Holger Meixner, Iryna Prots, Ursula Schlötzer-Schrehardt, Kristina Friedland, Beate Winner, Tiago F. Outeiro, Konstanze F. Winklhofer, Christine A. F. von Arnim, Wei Xiang, Jürgen Winkler, and Jochen Klucken, “Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress,” Scientific Reports, vol. 7, pp. 42942, 2017. View at Publisher · View at Google Scholar
  • Vaseem Raja, Umer Majeed, Hunseung Kang, Khursheed Iqbal Andrabi, and Riffat John, “Abiotic Stress: Interplay between ROS, Hormones and MAPKs,” Environmental and Experimental Botany, 2017. View at Publisher · View at Google Scholar
  • Ghazaleh Hajmousa, and Martin C. Harmsen, “Assessment of Energy Metabolic Changes in Adipose Tissue-Derived Stem Cells,” Adult Stem Cells, vol. 1553, pp. 55–65, 2017. View at Publisher · View at Google Scholar
  • Azadeh Aminzadeh, “Protective effect of tropisetron on high glucose induced apoptosis and oxidative stress in PC12 cells: roles of JNK, P38 MAPKs, and mitochondria pathway,” Metabolic Brain Disease, 2017. View at Publisher · View at Google Scholar
  • Long Ma, Jia-Xin Dong, Can Wu, Xue-Yi Li, Jing Chen, Hong Zhang, and Yi Liu, “Spectroscopic, Polarographic, and Microcalorimetric Studies on Mitochondrial Dysfunction Induced by Ethanol,” The Journal of Membrane Biology, 2017. View at Publisher · View at Google Scholar
  • Raouia Ghorbel, Ghada Ben Salah, Rania Ghorbel, Afif Ben Mahmoud, Imen Chamkha, Emna Mkaouar-Rebai, Leila Ammar-Keskes, and Faiza Fakhfakh, “Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?,” Environmental Science and Pollution Research, 2017. View at Publisher · View at Google Scholar
  • Asmaa F. Khafaga, Howaida M. Abu-Ahmed, Ahmed El-Khamary, Ibrahim M. Elmehasseb, and Hazem M. Shaheen, “Enhancement of equid distal limb wounds healing by topical application of silver nanoparticles,” Journal of Equine Veterinary Science, 2017. View at Publisher · View at Google Scholar
  • Sarika Srivastava, “The Mitochondrial Basis of Aging and Age-Related Disorders,” Genes, vol. 8, no. 12, pp. 398, 2017. View at Publisher · View at Google Scholar
  • Somayyeh Karami-Mohajeri, Ahmad Ahmadipour, Hamid-Reza Rahimi, and Mohammad Abdollahi, “Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research,” Archives of Industrial Hygiene and Toxicology, vol. 68, no. 4, 2017. View at Publisher · View at Google Scholar
  • Angela Mogavero, Maria Valeria Maiorana, Susanna Zanutto, Luca Varinelli, Fabio Bozzi, Antonino Belfiore, Chiara C. Volpi, Annunziata Gloghini, Marco A. Pierotti, and Manuela Gariboldi, “Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Jonathan C. Vacek, Jyotirmaya Behera, Akash K. George, Pradip K. Kamat, Anuradha Kalani, and Neetu Tyagi, “Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar
  • P.V.Sri Ramya, Lalita Guntuku, Srinivas Angapelly, Chander Singh Digwal, Uppu Jaya Lakshmi, Dilep Kumar Sigalapalli, Bathini Nagendra Babu, V.G.M. Naidu, and Ahmed Kamal, “Synthesis and biological evaluation of curcumin inspired imidazo[1,2- a ]pyridine analogues as tubulin polymerization inhibitors,” European Journal of Medicinal Chemistry, 2017. View at Publisher · View at Google Scholar
  • Lohanathan Bharathi Priya, Rathinasamy Baskaran, Chih-Yang Huang, and Viswanadha Vijaya Padma, “Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Marietta M. Budai, Aliz Varga, Tamas Biro, Zsofia Agod, Attila Bacsi, Kitti Pazmandi, Tünde Fekete, Attila Szabo, Hyelim Moon, Istvan Boldogh, and Arpad Lanyi, “Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells,” Redox Biology, vol. 13, pp. 633–645, 2017. View at Publisher · View at Google Scholar
  • Cheng Liu, Wei-Chang Lee, Bu-Miin Huang, Yi-Chen Chia, Yu-Chi Chen, and Yung-Chia Chen, “16-hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells,” Phytomedicine, 2017. View at Publisher · View at Google Scholar
  • Dhaneshree Bestinee Naidoo, Alisa Phulukdaree, Krishnan Anand, Vikash Sewram, and Anil Amichund Chuturgoon, “ Centella asiatica Fraction-3 Suppresses the Nuclear Factor Erythroid 2-Related Factor 2 Anti-Oxidant Pathway and Enhances Reactive Oxygen Species-Mediated Cell Death in Cancerous Lung A549 Cells ,” Journal of Medicinal Food, vol. 20, no. 10, pp. 959–968, 2017. View at Publisher · View at Google Scholar
  • Tian Liu, Mijung Lee, Jae-Jun Ban, Wooseok Im, Inhee Mook-Jung, and Manho Kim, “Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway,” Plos One, vol. 12, no. 1, pp. e0168859, 2017. View at Publisher · View at Google Scholar
  • Geliang Xu, Jiansheng Li, Weidong Jia, Jinliang Ma, Lixiang Meng, Wenbin Liu, and Decheng Wei, “Bovine lactoferricin P13 triggers ROS-Mediated Caspase-Dependent apoptosis in SMMC7721 cells,” Oncology Letters, vol. 13, no. 1, pp. 511–517, 2017. View at Publisher · View at Google Scholar
  • Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, and Faisal Thayyullathil, “Reactive oxygen species and cancer paradox: to promote or to suppress?,” Free Radical Biology and Medicine, 2017. View at Publisher · View at Google Scholar
  • Julia Jellusova, Matthew H Cato, John R Apgar, Parham Ramezani-Rad, Charlotte R Leung, Cindi Chen, Adam D Richardson, Elaine M Conner, Robert J Benschop, James R Woodgett, and Robert C Rickert, “Gsk3 is a metabolic checkpoint regulator in B cells,” Nature Immunology, 2017. View at Publisher · View at Google Scholar
  • Nadine Hempel, and Mohamed Trebak, “Crosstalk between Calcium and Reactive Oxygen Species Signaling in Cancer,” Cell Calcium, 2017. View at Publisher · View at Google Scholar
  • Sonia Missiroli, Alberto Danese, Tommaso Iannitti, Simone Patergnani, Mariasole Perrone, Maurizio Previati, Carlotta Giorgi, and Paolo Pinton, “Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017. View at Publisher · View at Google Scholar
  • Alberto Danese, Simone Patergnani, Massimo Bonora, Mariusz R. Wieckowski, Maurizio Previati, Carlotta Giorgi, and Paolo Pinton, “Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs),” Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017. View at Publisher · View at Google Scholar
  • Y. Li, and D. Ju, “The Application, Neurotoxicity, and Related Mechanism of Cationic Polymers∗∗Conflict of Interests: All the Figures and Table in “The application, neurotoxicity, and related mechanism of cationic polymers” are original, unpublished materials designed and prepared by Yubin Li and Dianwen Ju. The authors declared that there’s no conflict of interests.,” Neurotoxicity of Nanomaterials and Nanomedicine, pp. 285–329, 2017. View at Publisher · View at Google Scholar
  • Ting Xia, Jiahui Yao, Jin Zhang, Yu Zheng, Jia Song, and Min Wang, “Protective effects of Shanxi aged vinegar against hydrogen peroxide-induced oxidative damage in LO2 cells through Nrf2-mediated antioxidant responses,” RSC Adv., vol. 7, no. 28, pp. 17377–17386, 2017. View at Publisher · View at Google Scholar
  • Ana Podolski-Renić, Szilvia Bősze, Jelena Dinić, László Kocsis, Ferenc Hudecz, Antal Csámpai, and Milica Pešić, “Ferrocene–cinchona hybrids with triazolyl-chalcone linkers act as pro-oxidants and sensitize human cancer cell lines to paclitaxel,” Metallomics, 2017. View at Publisher · View at Google Scholar
  • Long Ma, Jun-Yi Liu, Jia-Xin Dong, Qi Xiao, Jie Zhao, and Feng-Lei Jiang, “ Toxicity of Pb 2+ on rat liver mitochondria induced by oxidative stress and mitochondrial permeability transition ,” Toxicol. Res., 2017. View at Publisher · View at Google Scholar
  • Chuanyan Zhao, Ningning Wang, Aihua Zhang, Changying Xing, Yanggang Yuan, Zhuyun Chen, Jia Qi, Suyan Duan, Zhimin Huang, Lin Wu, Bo Zhang, Huijuan Mao, Chengning Zhang, and Ming Zeng, “Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function,” Oncotarget, vol. 8, no. 13, pp. 20988–21000, 2017. View at Publisher · View at Google Scholar
  • Luigi Barrea, Giovanni Tarantino, Carolina Di Somma, Giovanna Muscogiuri, Paolo Emidio Macchia, Andrea Falco, Annamaria Colao, and Silvia Savastano, “Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–14, 2017. View at Publisher · View at Google Scholar
  • Elnaz Mohammad Alizadeh, Majid Mahdavi, Forough Jenani Fard, Solmaz Chamani, Fereshteh Farajdokht, and Pouran Karimi, “Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury,” Toxicology Mechanisms and Methods, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Benigno C. Valdez, Xiaowen Tang, Yang Li, David Murray, Yan Liu, Uday Popat, Richard E. Champlin, and Borje S. Andersson, “Epigenetic modification enhances the cytotoxicity of busulfan and 4-hydroperoxycyclophosphamide in AML cells,” Experimental Hematology, 2018. View at Publisher · View at Google Scholar
  • Aditi Jain, and Vibha Rani, “Assessment of herb-drug synergy to combat doxorubicin induced cardiotoxicity,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Aline Steinmetz, Luiza Steffens, Ana Moira Morás, Flávia Prezzi, Elizandra Braganhol, Jenifer Saffi, Rafael Scorsatto Ortiz, Helena M.T. Barros, and Dinara Jaqueline Moura, “In vitro model to study cocaine and its contaminants,” Chemico-Biological Interactions, vol. 285, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Karl-Josef Dietz, Corinna Wesemann, Melanie Wegener, and Thorsten Seidel, “Toward an Integrated Understanding of Retrograde Control of Photosynthesis,” Antioxidants & Redox Signaling, 2018. View at Publisher · View at Google Scholar
  • Graeme Preston, Faisal Kirdar, and Tamas Kozicz, “The role of suboptimal mitochondrial function in vulnerability to post-traumatic stress disorder,” Journal of Inherited Metabolic Disease, 2018. View at Publisher · View at Google Scholar
  • Jeong-Min Hong, and Sun-Mee Lee, “Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Gerardo Bosco, Alex Rizzato, Silvia Quartesan, Enrico Camporesi, Devanand Mangar, Matteo Paganini, Lorenzo Cenci, Sandro Malacrida, Simona Mrakic-Sposta, Sara Moretti, and Antonio Paoli, “Effects of the Ketogenic diet in overweight divers breathing Enriched Air Nitrox,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Sanatan Mishra, Aindrila Chattopadhyay, Shamreen Naaz, Arnab K. Ghosh, Asish Ranjan Das, and Debasish Bandyopadhyay, “Oleic acid ameliorates adrenaline induced dysfunction of rat heart mitochondria by binding with adrenaline: An isothermal titration calorimetry study,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Janka Vašková, and Ladislav Vaško, “Introductory Chapter: Unregulated Mitochondrial Production of Reactive Oxygen Species in Testing the Biological Activity of Compounds,” Medicinal Chemistry [Working Title], 2018. View at Publisher · View at Google Scholar
  • Siti Maisarah Hasenan, Saiful Anuar Karsani, and Zakiah Jubri, “Modulation of age related protein expression changes by gelam honey in cardiac mitochondrial rats,” Experimental Gerontology, vol. 113, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • Marzieh Rashedinia, Jamileh Saberzadeh, Tannaz Khosravi Bakhtiari, Solmaz Hozhabri, and Rita Arabsolghar, “Glycyrrhizic Acid Ameliorates Mitochondrial Function and Biogenesis Against Aluminum Toxicity in PC12 Cells,” Neurotoxicity Research, 2018. View at Publisher · View at Google Scholar
  • Eddie Hsiang-Hua Lai, Cheng-Ning Yang, Sze-Kwan Lin, Han-Wei Wang, Sang-Heng Kok, Chi-Yuan Hong, I-Hsuan Su, Hsiang Yang, and Jenny Zwei-Chieng Chang, “Metformin Ameliorates Periapical Lesions through Suppression of Hypoxia-induced Apoptosis of Osteoblasts,” Journal of Endodontics, 2018. View at Publisher · View at Google Scholar
  • Olga A. Borovik, and Olga I. Grabelnych, “Mitochondrial alternative cyanide-resistant oxidase is involved in an increase of heat stress tolerance in spring wheat,” Journal of Plant Physiology, 2018. View at Publisher · View at Google Scholar
  • Do Youn Jun, Won Young Jang, Ki Yun Kim, Mi Hee Woo, and Young Ho Kim, “Cytoprotective effect of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone (CMEP-NQ) is mediated by the inhibition of BAK-dependent mitochondrial apoptosis pathway,” Plos One, vol. 13, no. 10, pp. e0204585, 2018. View at Publisher · View at Google Scholar
  • Andrej Rusin, Colin Seymour, and Carmel Mothersill, “Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research,” International Journal of Radiation Biology, pp. 1–17, 2018. View at Publisher · View at Google Scholar
  • Samia Boukhenouna, Mark A. Wilson, Karim Bahmed, and Beata Kosmider, “Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • Alfredo Briones-Herrera, Dianelena Eugenio-Pérez, Jazmin Gabriela Reyes-Ocampo, Susana Rivera-Mancía, and José Pedraza-Chaverri, “New highlights on the health-improving effects of sulforaphane,” Food & Function, 2018. View at Publisher · View at Google Scholar
  • Yue Zhou, Qinggang Xu, Xinghua Zhou, Shuang Song, and Beiwei Zhu, “ Stress resistance and lifespan extension of Caenorhabditis elegans enhanced by peptides from mussel ( Mytilus edulis ) protein hydrolyzate ,” Food & Function, 2018. View at Publisher · View at Google Scholar
  • Kuheli Das, Belete B. Beyene, Amitabha Datta, Eugenio Garribba, Catarina Roma-Rodrigues, Ana Silva, Alexandra R. Fernandes, and Chen-Hsiung Hung, “ EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni( ii ) and Mn( ii ) complexes: cytotoxicity and anti-proliferative activity towards human cancer cell lines ,” New Journal of Chemistry, 2018. View at Publisher · View at Google Scholar
  • Maria Markaki, Konstantinos Palikaras, and Nektarios Tavernarakis, “Novel Insights Into the Anti-aging Role of Mitophagy,” 2018. View at Publisher · View at Google Scholar
  • Pilar Alberdi, Alejandro Cabezas-Cruz, Pedro Espinosa Prados, Margarita Villar Rayo, Sara Artigas-Jerónimo, and José de la Fuente, “The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Ting Xia, Bo Zhang, Wenhui Duan, Yu Li, Jin Zhang, Jia Song, Yu Zheng, and Min Wang, “Hepatoprotective efficacy of Shanxi aged vinegar extract against oxidative damage in vitro and in vivo,” Journal of Functional Foods, vol. 60, pp. 103448, 2019. View at Publisher · View at Google Scholar
  • Xiaodong Han, Xiaojia Jiang, Lanjie Guo, Yongxin Wang, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Zhigang Wang, and Dandan Cao, “ Anticarcinogenic potential of gold nanoparticles synthesized from Trichosanthes kirilowii in colon cancer cells through the induction of apoptotic pathway ,” Artificial Cells, Nanomedicine, and Biotechnology, vol. 47, no. 1, pp. 3577–3584, 2019. View at Publisher · View at Google Scholar
  • Ji Hee Kang, and Young Tag Ko, “Enhanced Subcellular Trafficking of Resveratrol Using Mitochondriotropic Liposomes in Cancer Cells,” Pharmaceutics, vol. 11, no. 8, pp. 423, 2019. View at Publisher · View at Google Scholar
  • Cristina Ribas Fürstenau, Izabel Cristina Custódio de Souza, and Marcos Roberto de Oliveira, “The effects of kahweol, a diterpene present in coffee, on the mitochondria of the human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide,” Toxicology in Vitro, pp. 104601, 2019. View at Publisher · View at Google Scholar
  • Yvoni Kirmanidou, Margarita Sidira, Athina Bakopoulou, Alexandros Tsouknidas, Oleg Prymak, Rigini Papi, Theodora Choli-Papadopoulou, Matthias Epple, Nikolaos Michailidis, Petros Koidis, and Konstantinos Michalakis, “Assessment of cytotoxicity and antibacterial effects of silver nanoparticle-doped titanium alloy surfaces,” Dental Materials, 2019. View at Publisher · View at Google Scholar
  • Zhiliang Li, Zengwu Shao, Songfeng Chen, Donghua Huang, Yizhong Peng, Sheng Chen, and Kaige Ma, “TIGAR impedes compression‐induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy,” Journal of Cellular Physiology, 2019. View at Publisher · View at Google Scholar
  • Martina Janků, Tereza Tichá, Lenka Luhová, and Marek PetřivalskýReactive Oxygen, Nitrogen and Sulfur Species in Plants, pp. 923–945, 2019. View at Publisher · View at Google Scholar
  • Chetna Jadala, Manda Sathish, T. Srinivasa Reddy, Velma Ganga Reddy, Ramya Tokala, Suresh K. Bhargava, Nagula Shankaraiah, Narayana Nagesh, and Ahmed Kamal, “Synthesis and in vitro cytotoxicity evaluation of β-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topoisomerase-II inhibition,” Bioorganic & Medicinal Chemistry, 2019. View at Publisher · View at Google Scholar
  • Guiying Li, Yi Liao, Junjie Hu, Lirong Lu, Yanan Zhang, Bin Li, and Taicheng An, “Activation of NF-κB pathways mediating the inflammation and pulmonary diseases associated with atmospheric methylamine exposure,” Environmental Pollution, 2019. View at Publisher · View at Google Scholar
  • Zhendong Zhu, Tomoko Kawai, Takashi Umehara, S.A. Masudul Hoque, Wenxian Zeng, and Masayuki Shimada, “Negative effects of ROS generated during linear sperm motility on gene expression and ATP generation in boar sperm mitochondria,” Free Radical Biology and Medicine, 2019. View at Publisher · View at Google Scholar
  • Jin-Young Lee, Whasun Lim, Jiyeon Ham, Jinyoung Kim, Seungkwon You, and Gwonhwa Song, “Ivermectin induces apoptosis of porcine trophectoderm and uterine luminal epithelial cells through loss of mitochondrial membrane potential, mitochondrial calcium ion overload, and reactive oxygen species generation,” Pesticide Biochemistry and Physiology, 2019. View at Publisher · View at Google Scholar
  • Yee Lian Tiong, Khuen Yen Ng, Rhun Yian Koh, Gnanajothy Ponnudurai, and Soi Moi Chye, “Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways,” Antioxidants, vol. 8, no. 7, pp. 198, 2019. View at Publisher · View at Google Scholar
  • Mroj Alassaf, Emily C Daykin, Jaffna Mathiaparanam, and Marc A Wolman, “Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function,” eLife, vol. 8, 2019. View at Publisher · View at Google Scholar
  • Chang Jia, Jian Zhang, Yingzhi Zhuge, Ke Xu, Jiahui Liu, Jinle Wang, Lei Li, and Maoping Chu, “ Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B ,” Free Radical Research, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Jalaja Veronica, Sambamurthy Chandrasekaran, Alti Dayakar, Moodu Devender, Vijay Kumar Prajapati, Shyam Sundar, and Radheshyam Maurya, “ Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani ,” The FEBS Journal, 2019. View at Publisher · View at Google Scholar
  • Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi, and Mallika Alvala, “Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin- Thiazole Hybrids as Anticancer Agents,” Anti-Cancer Agents in Medicinal Chemistry, vol. 19, no. 4, pp. 557–566, 2019. View at Publisher · View at Google Scholar
  • Nerella Sridhar Goud, S. Mahammad. Ghouse, Jatoth Vishnu, D. Komal, Venu Talla, Ravi Alvala, Jakkula Pranay, Janish Kumar, Insaf A. Qureshi, and Mallika Alvala, “Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents,” Bioorganic Chemistry, pp. 103016, 2019. View at Publisher · View at Google Scholar
  • Li Wang, Rufeng Xie, Zhijia Fan, Jie Yang, Wei Liang, Qiang Wu, Mei X. Wu, Zhicheng Wang, and Yuan Lu, “The contribution of oxidative stress to platelet senescence during storage,” Transfusion, 2019. View at Publisher · View at Google Scholar
  • Syed Morshed, Risheng Ma, Rauf Latif, and Terry F. Davies, “Cleavage region TSH receptor antibodies influence thyroid cell survival in vivo,” Thyroid, 2019. View at Publisher · View at Google Scholar
  • Alagie Jassey, Ching-Hsuan Liu, Chun Changou, Christopher Richardson, Hsue-Yin Hsu, and Liang-Tzung Lin, “Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy,” Cells, vol. 8, no. 4, pp. 290, 2019. View at Publisher · View at Google Scholar
  • Yuting Gao, Lianying Fang, Xiangxing Wang, Ruoni Lan, Meiyan Wang, Gang Du, Wenqiang Guan, Jianfu Liu, Margaret Brennan, Hongxing Guo, Charles Brennan, and Hui Zhao, “Antioxidant Activity Evaluation of Dietary Flavonoid Hyperoside Using Saccharomyces Cerevisiae as a Model,” Molecules, vol. 24, no. 4, pp. 788, 2019. View at Publisher · View at Google Scholar
  • Tomohiro Tanaka, Akiyuki Nishimura, Kazuhiro Nishiyama, Takumi Goto, Takuro Numaga-Tomita, and Motohiro Nishida, “Mitochondrial dynamics in exercise physiology,” Pflügers Archiv - European Journal of Physiology, 2019. View at Publisher · View at Google Scholar
  • Bedia Begüm Karakoçak, Sameer Patel, Nathan Ravi, and Pratim Biswas, “Investigating the Effects of Stove Emissions on Ocular and Cancer Cells,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Hiromu Ito, Hiromi Kurokawa, Hideo Suzuki, Hiroko P. Indo, Hideyuki J. Majima, and Hirofumi Matsui, “5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells,” Journal of Clinical Biochemistry and Nutrition, 2019. View at Publisher · View at Google Scholar