Table of Contents
Journal of Signal Transduction
Volume 2012, Article ID 791963, 13 pages
http://dx.doi.org/10.1155/2012/791963
Review Article

Neurospora crassa Light Signal Transduction Is Affected by ROS

A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninsky Prospekt, Moscow 119071, Russia

Received 17 May 2011; Accepted 23 June 2011

Academic Editor: Alexey M. Belkin

Copyright © 2012 Tatiana A. Belozerskaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the ascomycete fungus Neurospora crassa blue-violet light controls the expression of genes responsible for differentiation of reproductive structures, synthesis of secondary metabolites, and the circadian oscillator activity. A major photoreceptor in Neurospora cells is WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2, the products of genes white collar-1 and white collar-2. The photosignal transduction is started by photochemical activity of an excited FAD molecule noncovalently bound by the LOV domain (a specialized variant of the PAS domain). The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors. However, a critical analysis of the phototransduction mechanism considers the existence of residual light responses upon absence of WCC or its homologs in fungi. The data presented point at endogenous ROS generated by a photon stimulus as an alternative input to pass on light signals to downstream targets.