Table of Contents
Journal of Signal Transduction
Volume 2012, Article ID 807682, 12 pages
Review Article

Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

1Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Italy
2Department of Biotechnology, University of Siena, 53100 Siena, Italy

Received 19 July 2011; Accepted 24 August 2011

Academic Editor: Alexey M. Belkin

Copyright © 2012 Luca Goitre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, immune surveillance, inflammatory response, tumor progression, and metastasis. However, the molecular mechanisms underlying the fine-tuned functional communication between cadherins and integrins are still elusive. This paper focuses on recent findings towards the involvement of reactive oxygen species (ROS) in the regulation of cell adhesion and signal transduction functions of integrins and cadherins, pointing to ROS as emerging strong candidates for modulating the molecular crosstalk between cell-matrix and cell-cell adhesion receptors.