Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
Table 10
Litter size and viability index of the generation
rat pups exposed to SE5-OH during gestation and through lactation of the dams.
Dose (mg/kg/day)
0
200
1000
2000
Number of total offspring at birth
Males
24
23
22
22
Females
24
23
22
22
Total
24
23
22
22
(M/F)
(183/168)
(169/169)
(162/144)
(147/157)
Number of live offspring at birth
Males
24
23
22
22
Females
24
23
22
22
Total
24
23
22
22
(M/F)
(179/166)
(167/165)
(159/140)
(146/157)
Number of live offspring on PND
4 before culling
Males
24
23
22
22
Females
24
23
22
22
Total
24
23
22
22
(M/F)
(178/160)
(166/164)
(156/137)
(144/154)
Number of live offspring on PND
4 after culling
Males
24
23
21
22
Females
24
23
21
22
Total
24
23
21
22
Number of live offspring on PND 21
Males
24
23
21
22
Females
24
23
21
22
Total
24
23
21
22
Viability (%)
PND 0
24
23
22
22
PND 4
24
23
22
22
PND 21
24
23
21
22
Mean ± standard deviation; : number of litters; PND: postnatal
day; index: PND 0: (number
of live offspring born alive/number of offspring born), PND 4: (number of
offspring alive on PND 4/number of offspring born
alive), PND 21: (number
of live weanlings/number of live offspring after culling).