Journal of Toxicology / 2009 / Article / Tab 3 / Research Article
Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient Table 3 Body weight and food consumption in male and female Sprague-Dawley rats during the
two-generation reproductive toxicity study.
Generation F0 F1 Dose (mg/kg/day) Gender Period (days) 0 200 1000 2000 0 200 1000 2000 Body weight (g) Male Premating 0
1
9
5
.
9
±
6
.
6
1
9
6
.
5
±
5
.
7
1
9
6
.
2
±
6
.
3
1
9
5
.
5
±
6
.
2
5
9
.
6
±
4
.
9
#
5
9
.
7
±
5
.
0
5
9
.
4
±
5
.
7
5
7
.
1
±
5
.
1
70
5
4
0
.
0
±
4
7
.
2
5
6
0
.
1
±
5
6
.
6
5
3
4
.
3
±
4
6
.
4
5
3
9
.
3
±
4
1
.
2
4
5
1
.
8
±
3
5
.
1
461.±32.1
4
4
2
.
8
±
3
7
.
8
4
4
5
.
5
±
3
4
.
9
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
3
)
(
𝑛
=
2
3
)
(
𝑛
=
2
1
)
(
𝑛
=
2
2
)
Female Premating 0
1
5
2
.
2
±
8
.
5
1
5
2
.
5
±
6
.
9
1
5
1
.
0
±
6
.
9
1
5
1
.
2
±
6
.
8
5
5
.
4
±
6
.
0
5
7
.
0
±
5
.
8
5
7
.
6
±
4
.
8
5
4
.
8
±
5
.
5
70
3
0
3
.
9
±
3
5
.
6
2
9
8
.
3
±
2
1
.
5
2
8
9
.
2
±
2
2
.
4
2
8
3
.
0
±
1
9
.
1
∗
2
6
6
.
6
±
2
2
.
9
2
7
0
.
0
±
2
6
.
8
2
6
3
.
2
±
2
1
.
0
2
5
2
.
9
±
1
7
.
1
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
6
)
(
𝑛
=
2
4
)
(
𝑛
=
2
3
)
(
𝑛
=
2
0
)
(
𝑛
=
2
2
)
Gestation 7
3
3
7
.
9
±
2
8
.
8
3
3
3
.
9
±
2
1
.
3
3
2
3
.
3
±
2
2
.
7
3
1
8
.
5
±
2
1
∗
3
5
8
.
9
±
3
2
.
3
3
6
7
.
1
±
3
4
.
9
3
5
2
.
6
±
2
9
.
6
3
3
4
.
7
±
2
0
.
7
∗
14
3
7
1
.
0
±
2
9
.
5
3
6
4
.
0
±
2
3
.
3
3
5
5
.
4
±
2
3
.
8
3
4
9
.
3
±
2
3
.
4
∗
3
9
5
.
4
±
3
4
.
4
4
0
0
.
9
±
3
5
.
5
3
8
3
.
4
±
2
9
.
6
3
6
7
.
6
±
2
2
.
9
∗
20
4
4
3
.
0
±
3
6
.
4
4
4
0
.
2
±
2
5
.
4
4
3
4
.
7
±
2
6
.
7
4
2
8
.
9
±
2
3
.
6
4
7
4
.
9
±
4
0
.
5
4
7
3
.
3
±
3
9
.
1
4
5
3
.
9
±
3
8
.
9
4
3
7
.
3
±
3
4
.
9
∗
∗
(
𝑛
=
2
5
)
(
𝑛
=
2
4
)
(
𝑛
=
2
2
)
(
𝑛
=
2
2
)
(
𝑛
=
1
8
)
(
𝑛
=
1
9
)
(
𝑛
=
1
9
)
(
𝑛
=
2
1
)
Lactation 21
3
5
5
.
0
±
2
4
.
2
3
4
5
.
8
±
2
0
.
4
3
4
5
.
3
±
2
1
.
7
3
4
3
.
0
±
1
9
.
5
3
6
5
.
3
±
2
5
.
6
3
7
0
.
8
±
2
8
.
0
3
6
8
.
0
±
2
2
.
8
3
5
5
.
8
±
1
4
.
8
(
𝑛
=
2
4
) (
𝑛
=
2
3
) (
𝑛
=
2
1
) (
𝑛
=
2
2
) (
𝑛
=
1
8
) (
𝑛
=
1
7
) (
𝑛
=
1
8
) (
𝑛
=
1
9
) Body weight gain (g) Male Premating 0–70
3
4
4
.
1
±
4
5
.
1
3
6
3
.
6
±
5
4
.
4
3
3
8
.
1
±
4
3
.
7
3
4
3
.
8
±
4
0
.
0
3
9
2
.
3
±
3
4
.
1
4
0
1
.
8
±
3
0
.
2
3
8
3
.
4
±
3
4
.
1
3
8
8
.
4
±
3
2
.
1
Female Premating 0–70
1
5
1
.
7
±
3
1
.
1
1
4
5
.
9
±
2
0
.
4
1
3
8
.
2
±
1
9
.
3
1
3
1
.
9
±
1
6
.
5
∗
2
1
1
.
2
±
2
0
.
8
2
1
3
.
0
±
2
5
.
0
2
0
5
.
4
±
1
9
.
3
1
9
8
.
1
±
1
6
.
9
Gestation 0–7
3
3
.
2
±
7
.
1
3
1
.
3
±
5
.
5
2
9
.
6
±
8
.
9
3
0
.
7
±
7
.
9
3
6
.
8
±
7
.
7
3
4
.
6
±
8
.
7
3
2
.
1
±
9
.
3
3
3
.
3
±
7
.
9
0–14
6
6
.
3
±
1
2
.
7
6
1
.
4
±
8
.
8
6
1
.
7
±
8
.
0
6
1
.
5
±
1
2
.
4
7
3
.
2
±
8
.
4
6
8
.
4
±
1
2
.
1
6
2
.
8
±
1
0
.
7
∗
6
6
.
2
±
1
1
.
8
0–20
1
3
8
.
3
±
2
2
.
3
1
3
7
.
6
±
1
6
.
4
1
4
1
.
0
±
1
1
.
0
1
4
1
.
0
±
1
8
.
5
1
5
2
.
8
±
1
3
.
0
1
4
0
.
8
±
2
4
.
5
1
3
3
.
3
±
2
0
.
8
∗
∗
1
3
6
.
0
±
2
6
.
5
Lactation 0–21
1
.
6
±
2
0
.
3
−
2
.
4
±
2
0
.
2
6
.
8
±
2
0
.
8
3
.
4
±
1
3
.
9
−
2
0
.
3
±
2
0
.
5
−
1
7
.
4
±
2
5
.
4
−
7
.
7
±
2
3
.
4
−
5
.
5
±
2
3
.
0
Food consumption (g) Male Premating 70
2
6
.
2
±
1
.
9
2
6
.
9
±
1
.
8
2
5
.
4
±
1
.
6
2
5
.
1
±
1
.
8
3
0
.
5
±
2
.
0
3
1
.
3
±
1
.
8
2
9
.
0
±
1
.
8
2
8
.
9
±
1
.
9
Female Premating 70
1
9
.
0
±
1
.
7
1
8
.
5
±
1
.
6
1
7
.
6
±
1
.
2
∗
1
6
.
3
±
0
.
9
∗
∗
2
0
.
3
±
2
.
1
2
0
.
6
±
1
.
5
1
9
.
2
±
1
.
3
1
7
.
5
±
1
.
1
∗
∗
Gestation 7
2
2
.
6
±
1
.
7
2
2
.
1
±
1
.
9
2
0
.
7
±
2
.
1
∗
∗
2
0
.
4
±
2
.
4
∗
∗
2
4
.
4
±
1
.
9
2
4
.
3
±
2
.
9
2
2
.
6
±
3
.
1
2
1
.
4
±
2
.
1
∗
∗
14
2
4
.
8
±
2
.
4
2
4
.
2
±
2
.
2
2
3
.
1
±
2
.
0
∗
2
2
.
8
±
2
.
3
∗
∗
2
6
.
3
±
2
.
2
2
6
.
3
±
2
.
8
2
4
.
7
±
2
.
6
2
3
.
7
±
2
.
6
∗
∗
20
2
6
.
0
±
2
.
4
2
5
.
7
±
2
.
6
2
6
.
0
±
2
.
2
2
5
.
1
±
2
.
1
2
7
.
7
±
2
.
1
2
6
.
3
±
2
.
5
2
5
.
8
±
2
.
1
2
6
.
4
±
2
.
6
Lactation 21
6
8
.
4
±
8
.
5
6
8
.
8
±
3
.
7
6
9
.
4
±
4
.
0
6
7
.
4
±
5
.
4
6
7
.
2
±
6
.
6
6
7
.
9
±
5
.
3
6
4
.
1
±
6
.
4
6
5
.
7
±
9
.
2
Mean ± standard
deviation; significantly different from control:
∗
𝑃
<
.
0
5
,
∗
∗
𝑃
<
.
0
1
;
#
the start of dosing for the
F
0
groups
was at six weeks of age. The start of dosing for the
F
1
group was on day 21
postparturition, to maintain SE5-OH ingestion via lactation;
𝑛
: number of male and female rats per dose
group.
