Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient

Table 5

Effect of SE5-OH administration on the reproductive performance of the F₀ generation rat dams.

Dose (mg/kg/day)	Mean estrus cycle	Incidence of irregular estrus cycle	Mating period		Copulation index (%)^A	Fertility index (%)^B
			Number of estrus	Day of conceiving
0	4.26±0.43#		0.0±0.0	2.5±1.8	100.0	96.2
	(𝑛=25)	1/26	(𝑛=26)	(𝑛=26)	(26/26)	(25/26)
200	4.18±0.32		0.0±0.0	2.8±1.6	92.3	100.0
	(𝑛=24)	2/26	(𝑛=26)	(𝑛=24)	(24/26)	(24/24)
1000	4.21±0.40		0.0±0.0	2.9±2.7	92.3	91.7
	(𝑛=26)	0/26	(𝑛=26)	(𝑛=24)	(24/26)	(22/24)
2000	4.15±0.38		0.0±0.0	3.3±2.5	96.2	88.0
	(𝑛=24)	2/26	(𝑛=26)	(𝑛=25)	(25/26)	(22/25)

#Mean ± standard deviation; ^Anumber of copulated females/number of pairs; ^Bnumber of pregnant females/number of copulated females; 𝑛: number of mating pairs.