Journal of Toxicology / 2009 / Article / Tab 1

Research Article

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes

Table 1

ATP levels in rats hepatocytes after fluconazole or itraconazole incubations. Control and SKF 525A pretreated hepatocytes were exposed to various concentrations of fluconazole or itraconazole for 6 hours.

ATP (nmol/ cells)
DrugControl hepatocytes5 mg/kg SKF 525A pretreated hepatocytes25 mg/kg SKF 525A pretreated hepatocytes

None (control)
Fluconazole (mM)
0.001
0.01
0.1
1.0
Itraconazole (mM)
0.001
0.01
0.1
1.0

Values are mean   sd of 3 separate experiments. a–dMeans with different superscript differ significantly ( ) in the same column. x-yMeans with different superscript differ significantly ( ) in the same row.

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