Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
ATP levels in rats hepatocytes after fluconazole or itraconazole incubations. Control and SKF 525A pretreated hepatocytes were exposed to various concentrations of fluconazole or itraconazole for 6 hours.
ATP (nmol/ cells)
5 mg/kg SKF 525A pretreated hepatocytes
25 mg/kg SKF 525A pretreated hepatocytes
Values are mean sd of 3 separate experiments. a–dMeans with different superscript differ significantly () in the same column. x-yMeans with different superscript differ significantly () in the same row.
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