In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

Figure 1

Time course of oxidant production by NR8383 cells after incubation with crocidolite and zymosan. Oxidant production was measured as increased chemiluminescence of lucigenin (in relative light units, RLU). Each point represents the mean ± SD of three experiments. Control (*); Crocidolite 15 $\mu$g/cm² (□), 30 $\mu$g/cm² (∆), and 60 $\mu$g/cm² (∘); Zymosan 7.5 $\mu$g/cm² (■), 15 $\mu$g/cm² (▲), and 30 $\mu$g/cm² (●).