The Influence of Bovine Milk High or Low in Isoflavones on Hepatic Gene Expression in Mice

Table 1

A list of functional gene groupings included in the array assay.

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Drug Transporters:

Metallothioneins: Mt2, Mt3.

P-Glycoprotein Family: Abcb1a, Abcb1b, Abcb4, Abcc1, Gpi1.

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Phase I Metabolising Enzymes:

P450 Family: Cyp11b2, Cyp17a1, Cyp19a1, Cyp1a1, Cyp1a2, Cyp27b1, Cyp2b10, Cyp2C29, Cyp2e1, Cyp4b1.

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Phase II Metabolising Enzymes:

Carboxylesterases: Ces1, Ces2.

Decarboxylases: Gad1, Gad2.

Dehydrogenases: Adh1, Adh4, Adh5, Alad, Aldh1a1, Hsd17b1, Hsd17b2, Hsd17b3.

Glutathione Peroxidases: Gpx1, Gpx2, Gpx3, Gpx5, Gsta1, Gsta3, Gsta4, Gstm1, Gstm2, Gstm3, Gstm4, Gstm5, Gstp1, Gstt1, Gstz1, Lpo,

Mpo.

Hydrolases: Ephx1, Faah, Fbp1.

Kinases: Hk2, Pklr, Pkm2.

Lipoxygenases: Alox12, Alox15, Alox5, Apoe.

Oxidoreductases: Blvra, Blvrb, Cyb5r3 (Dia1), Gpx1, Gpx2, Gsr, Mthfr, Nos3, Nqo1, Srd5a1, Srd5a2.

Paraoxonases: Pon1, Pon2, Pon3.

Sulfotransferases: Chst1, Gsta3, Gstm2, Gstm3, Gstm5, Gstp1, Gstt1, Mgst1, Mgst2, Mgst3.

Transferases: Nat1, Nat2, Comt, Ggt1.

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Other Genes Related to Drug Metabolism: Abp1, Ahr, Arnt, Asna1, Gckr, Marcks, Smarcal1, Snn.

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