The Loss of HIF1𝜶 Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts

Figure 7

Lipid peroxidation under CdCl₂ treatment. Lipid peroxidation levels were determined in wild type (WT, white bars) and HIF1α  −/− (black bars) by measuring malondialdehyde (MDA) levels. Cells were left untreated (Ctrl), or treated with 5 μM CdCl₂ (Cd²⁺) for 24 hours or 2 mM H₂O₂ for 4 hours. *𝑃<0.05 compared to respective controls, 𝑛=4. ^#𝑃<0.05, significant compared to wild-type cells, 𝑛=4.