Research Article
Ethylene Oxide: Acute Four-Hour and One-Hour Inhalation Toxicity Testing in Rats
Table 3
Clinical observations, mortality rates, and day of death for male rats following 1-hour exposure to EO.
| | Exposure group (ppm) | Clinical signs | Mortality | Number found dead
Observation day | | During exposure | During two days of postexposure period | Number dead/total | 0a | 1 | 2 |
| | 6161 ppm | Absent startle reflex, gasping | Unkempt fur, decreased respiration rate, hypoactivity, ataxia, tremors | 4/5 | 0b | 3 | 1 |
| | 5546 ppm | Absent startle reflex | Unkempt fur, decreased respiration rate, hypoactivity, ataxia, tremors | 1/5 | 0 | 0 | 1 |
| | 4827 ppm | Absent startle reflex | Perioral/perinasal encrustation | 0/5 | 0 | 0 | 0 |
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aDay 0 is exposure day. Days 1 and 2 are days following exposure day.
bNumber of animals found dead on a particular day.
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