Research Article
Ethylene Oxide: Acute Four-Hour and One-Hour Inhalation Toxicity Testing in Rats
Table 4
Clinical observations, mortality rates, and day of death for female rats following 1-hour exposure to EO.
| Exposure group (ppm) | Clinical signs | Mortality | Number found dead Observation day | During exposure | During three days of postexposure period | Number dead/total | 0a | 1 | 2 |
| 4827 ppm | Absent startle reflex | Perinasal wetness, pericular/perioral/perinasal encrustation, unkempt fur, decreased respiration rate, hypoactivity | 5/5 | 0b | 1 | 2 |
| 4202 ppm | | Periocular/perinasal encrustation, unkempt fur, decreased respiration rate, hypoactivity, ataxia, tremors | 1/5 | 0 | 4 | 1 |
| 3966 ppm | | Unkempt fur, decreased respiration rate, hypoactivity, ataxia, tremors | 2/5 | 0 | 0 | 1 |
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aDay 0 is exposure day. Days 1 and 2 are days following exposure day.
bNumber of animals found dead on a particular day.
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