Journal of Toxicology / 2011 / Article / Tab 1

Research Article

Exposure of the Main Italian River Basin to Pharmaceuticals

Table 1

Literature values (S. Castiglioni et al., 2004; R. Andreozzi et al., 2003; Banca dati Farmacoambiente; Drugbank) of the physicochemical properties and degradation behaviour of the selected pharmaceuticals.

Class of drugsPharmaceuticalMolecular weight (g/mol) Log Stability in water

β-BlockerAtenolol266.30.5Stable for 40 d (5–25°C) 45.2 h pH 7.4 (UV ray)Moderate stability

Anti-inflammatory Paracetamol 151.160.46 (experim.)
0.27 (predicted)
Nimesulide308.32.56
Metoprolol2670.5
Propranolol2593.65

Ulcer healing Ranitidine  314.41.3 (experim.)Stable 160 h pH 6.18,65°CProlonged stability
0.79 (predicted)
Diuretic Furosemide  330.71.4 (experim.)Stable 90 d pH 5.2Prolonged stability
2.71 (predicted)Stable 96% 240 d pH 5.2
Lipid regulator Atorvastatin  558.65.7 (experim.)
4.24 (predicted)
AntiepilepticCarbamazepine  2362.3 (experim.) 100 dProlonged stability
2.10 (predicted)
AntibacterialMetronidazole  171−0.1 (experim.)
−0.15 (predicted)

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