Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

Table 4

Absolute and relative (to body weight) liver weights of male SD rats following 5 days, 2 weeks, 4 weeks, and 13 weeks of daily exposure of TCP by oral gavage.

Time point	Liver weight	TCP dose (mg/kg/day)
		0	10	25	50	100	200
5 Days	g^1	13.1±1.1^3	13.4±1.7	13.5±1.3	13.1±2.0	15.6±1.7 **	16.1±1.4 ***
	%^2	4.36±0.20	4.44±0.29	4.48±0.35	4.58±0.37	5.16±0.67 ***	5.48±0.32 ***
2 Weeks	g	13.8±1.5	15.2±1.3	15.9±1.7 *	17.9±2.1 ***	19.5±1.8 ***	21.4±2.3 ***
	%	3.89±0.24	4.25±0.27 *	4.43±0.25 ***	4.96±0.34 ***	5.56±0.23 ***	6.36±0.32 ***
4 Weeks	g	16.0±3.3	16.4±2.1	17.4±2.6	20.0±3.7 *	23.2±2.0 ***	25.4±4.8 ***
	%	3.90±0.68	3.86±0.24	4.23±0.28	4.73±0.49 **	5.75±0.32 ***	6.54±0.78 ***
13 Weeks	g	16.8±2.9	21.4±2.7	24.2±3.3 **	27.5±5.5 ***	33.6±7.3 ***	38.9±7.2 ***
	%	3.10±0.20	3.65±0.13	4.36±0.42 ***	5.46±0.62 ***	7.11±0.86 ***	9.40±1.11 ***

¹g: grams.
²%: [liver weight/body weight] × 100.
³mean ± standard deviation for 𝑛=10 except for the following groups: 𝑛=9 (25 mg/kg/day and 50 mg/kg/day, 13 weeks); 𝑛=11 (0 mg/kg/day, 5 days, 2 weeks, and 4 weeks); 𝑛=12 (0 mg/kg/day, 13 weeks).
* 𝑃<0.05 compared to control.
** 𝑃<0.01 compared to control.
*** 𝑃<0.001 compared to control.