Table 2: Physiological parameters distributions used in the Monte Carlo simulations of the internal dose metrics with the steady-state algorithm.

Parameter^{(a)}

Subpopulation

Median age (range)

Adults 41 (18–64)

Neonate 14 d (0–30 d)

Infants 6.5 m (1–12 mo)

Toddlers 2 (1–3)

Children and adolescents 12 (4–17)

Elderly 78 (65–90)

Pregnant women 29 (15–44)

Sampled parameters

Body weight (BW) (Kg: m ± SD, range)

76 ± 17, 37–152^{(b)}

4 ± 1, 2–7^{(c)}

9 ± 2, 3–15^{(b)}

13 ± 2, 7–32^{(b)}

36 ± 16, 9–113^{(b)}

72 ± 16, 33–155^{(b)}

70 ± 18, 36–152^{(d)}

[CYP2E1] (pmol/mg MSP: m ± SD, range)

49 ± 2, 11–130^{(e)}

18 ± 14, 1–56^{(c)}

36 ± 21, 10–86^{(c)}

42 ± 18, 18–74^{(c)}

53 ± 23, 22–95^{(c)}

Calculated parameters^{(b), (g)}

Alveolar ventilation rate (Qp)

Liver volume (Vl)

Liver blood flow (Ql)

Log normal distributions for sampled parameters and normal distributions for “variability terms.” All indicated means are arithmetic, except note (see below). P^{3}M database [28].[19]. Distribution for non-pregnant women taken from P^{3}M database [28], and, to each of these values, the mean body weight increase at any week during pregnancy (normal distribution of 5 ± 4.4 kg (0–14.1)) based on data from ICRP was added [16, 29]. (Geometric mean ± geometric standard deviation) [20]. Same as for adults. [16]. CYP2E1: cytochrome p-450 2E1; MSP: microsomal protein; SD: standard deviation.