Modeling the Human Kinetic Adjustment Factor for Inhaled Volatile Organic Chemicals: Whole Population Approach versus Distinct Subpopulation Approach
Table 4
Distribution statistics of various dose metrics in each subpopulation based on 100,000 Monte Carlo iterations and the entire Canadian populations for constant inhalation exposure.
Subpopulation Statistics
Dose metrics
Benzene
1,4-Dioxane
CAss
RAM
CAss
RAM
Adults
1st percentile
0.76
35
285
531
Median
1.04
46
763
806
99th percentile
1.36
62
2119
1291
Neonates
1st percentile
0.88
20
682
371
Median
1.26
39
2299
686
99th percentile
1.76
55
6486
1149
Infants
1st percentile
0.8
33
420
526
Median
1.11
45
1150
787
99th percentile
1.44
60
2928
1246
Toddlers
1st percentile
0.79
35
382
534
Median
1.08
47
968
804
99th percentile
1.38
60
2099
1271
Children and adolescents
1st percentile
0.77
35
352
538
Median
1.04
47
774
814
99th percentile
1.35
61
1744
1293
Elderly
1st percentile
0.76
35
286
530
Median
1.04
46
766
807
99th percentile
1.37
62
2144
1291
Pregnant Women
1st percentile
0.85
41
372
673
Median
1.16
55
995
1050
99th percentile
1.49
73
2698
1686
Canadian population
1st percentile
0.76
35
299
533
Median
1.04
47
779
808
99th percentile
1.36
63
2139
1306
CAss: blood concentration of parent compound (μg/L); RAM: rate of metabolism (μg/h-L of liver).
