Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2012 (2012), Article ID 589520, 10 pages
http://dx.doi.org/10.1155/2012/589520
Research Article

Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

1R&D Centre, Natural Remedies, Plot No. 5B, Veerasandra Industrial Area, 19th K.M. Stone, Hosur Road, Electronic City, Bangalore, Karnataka 560 100, India
2Indian Institute of Toxicology, 32/A/01, Hadapsar Industrial Estate, Pune, Maharashtra 411 013, India

Received 30 July 2012; Revised 13 September 2012; Accepted 14 September 2012

Academic Editor: Y. James Kang

Copyright © 2012 Joseph Joshua Allan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Joshua, K. S. Goudar, A. Damodaran, N. Sameera, and A. Amit, “Acute oral toxicity evaluation of some polyherbal formulations in albino wistar rats,” International Journal of Pharmacology, vol. 4, no. 5, pp. 388–392, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. J. Joshua, K. S. Goudar, N. Sameera et al., “Safety assessment of herbal formulations, Rumbion and Tyrel in Albino Wistar rats,” American Journal of Pharmacology and Toxicology, vol. 5, no. 1, pp. 42–47, 2010. View at Google Scholar · View at Scopus
  3. L. B. Kouitcheu Mabeku, V. Penlap Beng, J. Kouam, O. Essame, and F. X. Etoa, “Toxicological evaluation of ethyl acetate extract of Cylicodiscus gabunensis stem bark (Mimosaceae),” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 598–606, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. I. B. Koul and A. Kapil, “Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation,” Indian Journal of Pharmacology, vol. 26, no. 4, pp. 296–300, 1994. View at Google Scholar · View at Scopus
  5. N. P. Trivedi and U. M. Rawal, “Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice,” Indian Journal of Experimental Biology, vol. 39, no. 1, pp. 41–46, 2001. View at Google Scholar · View at Scopus
  6. K. Jarukamjorn and N. Nemoto, “Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide,” Journal of Health Science, vol. 54, no. 4, pp. 370–381, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Kapil, I. B. Koul, S. K. Banerjee, and B. D. Gupta, “Antihepatoxic effects of major diterpenoid constituents of Andrographis paniculata,” Biochemical Pharmacology, vol. 46, no. 1, pp. 182–185, 1993. View at Publisher · View at Google Scholar · View at Scopus
  8. P. K. S. Visen, B. Shukla, G. K. Patnaik, and B. N. Dhawan, “Andrographolide protects rat hepatocytes against paracetamol-induced damage,” Journal of Ethnopharmacology, vol. 40, no. 2, pp. 131–136, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Pramyothin, W. Udomuksorn, S. Poungshompoo, and C. Chaichantipyuth, “Hepatoprotective effect of Andrographis paniculata and its constituent, andrographolide, on ethanol hepatotoxicity in rats,” Asia Pacific Journal of Pharmacology, vol. 9, no. 2, pp. 73–78, 1993. View at Google Scholar · View at Scopus
  10. B. P. Saraswat, P. K. S. Visen, G. K. Patnaik, and B. N. Dhawan, “Effect of andrographolide against galactosamine-induced hepatotoxicity,” Fitoterapia, vol. 66, no. 5, pp. 415–420, 1995. View at Google Scholar · View at Scopus
  11. S. K. Chaudhuri, “Influence of Andrographis paniculata (Kalmegh) on bile flow and hexabarbitone sleeping in experimental animals,” Indian Journal of Experimental Biology, vol. 16, no. 7, pp. 830–832, 1978. View at Google Scholar · View at Scopus
  12. B. K. Chandan, A. K. Sharma, and K. K. Anand, “Boerhaavia diffusa: a study of its hepatoprotective activity,” Journal of Ethnopharmacology, vol. 31, no. 3, pp. 299–307, 1991. View at Google Scholar · View at Scopus
  13. K. K. Chakraborti and S. S. Handa, “Antihepatotoxic activity of Boerhaave diffusa,” Indian Drugs, vol. 27, no. 13, pp. 161–166, 1989. View at Google Scholar · View at Scopus
  14. P. Chattopadhyay, S. S. Agrawal, and A. Garg, “Liver regenerative effect of Phyllanthus amarus Linn. against alcohol induced liver cell injury in partially hepatectomised albino rats,” International Journal of Pharmacology, vol. 2, no. 4, pp. 426–430, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Mehrotra, S. Rawat, D. K. Kulshreshtha, P. Goyal, G. K. Patnaik, and B. N. Dhawan, “In vitro effect of Phyllanthus amarus on hepatitis B virus,” Indian Journal of Medical Research A, vol. 93, pp. 71–73, 1991. View at Google Scholar · View at Scopus
  16. A. Masood and K. S. Ranjan, “The effect of aqueous plant extracts on growth and aflatoxin production by Aspergillus flavus,” Letters in Applied Microbiology, vol. 13, no. 1, pp. 32–34, 1991. View at Google Scholar · View at Scopus
  17. Organisation for Economic Co-operation and Development (OECD), “OECD guideline for testing of chemicals: Guideline 420, Acute oral toxicity—Fixed dose procedure,” OECD, Paris, France, 2001.
  18. Ministry of Health & Family Welfare, “Schedule Y. Drugs and Cosmetics [8th Amendment] Rules-1988,” Government of India, 1991.
  19. Organisation for Economic Co-operation and Development (OECD), “OECD guideline for testing of chemicals: Test guideline No. 408, Repeated dose 90-day oral toxicity study in rodents,” OECD, Paris, France, 1998.
  20. Ministry of Health & Family Welfare, “Schedule Y. Drugs and Cosmetics [2nd Amendment] Rules-2005,” Government of India, 2005.
  21. B. Björkholm, C. M. Bok, A. Lundin, J. Rafter, M. L. Hibberd, and S. Pettersson, “Intestinal microbiota regulate xenobiotic metabolism in the liver,” PLoS ONE, vol. 4, no. 9, Article ID e6958, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. S. P. Jain, A. R. Tekade, U. M. Joshi, R. H. Kale, and R. N. Purohit, “Protective effect of Gingko biloba on antitubercular drugs induced hepatotoxicity in rats,” Indian Drugs, vol. 42, no. 3, pp. 167–171, 2005. View at Google Scholar · View at Scopus
  23. N. Y. Gond and S. S. Khadabadi, “Hepatoprotective activity of Ficus carica leaf extract on rifampicin-induced hepatic damage in rats,” Indian Journal of Pharmaceutical Sciences, vol. 70, no. 3, pp. 364–366, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. B. Kamble, R. K. Dumbre, and V. D. Rangari, “Hepatoprotective activity studies of herbal formulations,” International Journal of Green Pharmacy, vol. 2, no. 3, pp. 147–151, 2008. View at Google Scholar
  25. A. J. Joshua, V. Vijayabalaji, K. S. Goudar, N. Sameera, and A. Amit, “Safety assessment of some poultry formulations on acute exposure in rats,” Indian Journal of Natural Products, vol. 24, pp. 10–16, 2008. View at Google Scholar
  26. V. Vijayabalaji, A. J. Joshua, P. G. Kumar, B. Murali, M. L. Suryanarayana, and A. Amit, “Evaluation of safety of Naturaliv liquid and Zist liquid on acute oral exposure in rats,” Journal of Pharmacology and Toxicology, vol. 5, pp. 450–459, 2010. View at Google Scholar
  27. F. Homburger, “In vivo testing in the study of toxicity and safety evaluation,” in A Guide to General Toxicology, J. K. Marquis, Ed., Karger Continuing Education Series, pp. 268–293, New York, NY, USA, 1989. View at Google Scholar
  28. B. Schilter, C. Andersson, R. Anton et al., “Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements,” Food and Chemical Toxicology, vol. 41, no. 12, pp. 1625–1649, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Lakmichi, F. Z. Bakhtaoui, C. A. Gadhi et al., “Toxicity profile of the aqueous ethanol root extract of Corrigiola telephiifolia pourr. (Caryophyllaceae) in rodents,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 317090, 10 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Aragon and Z. M. Younossi, “When and how to evaluate mildly elevated liver enzymes in apparently healthy patients,” Cleveland Clinic Journal of Medicine, vol. 77, no. 3, pp. 195–204, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. C. V. Chandrasekaran, K. Sundarajan, K. David, and A. Agarwal, “In vitro efficacy and safety of poly-herbal formulations,” Toxicology In Vitro, vol. 24, no. 3, pp. 885–897, 2010. View at Publisher · View at Google Scholar · View at Scopus