Research Article
Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats
Table 4
Clinical chemistry data (mean ± SD) of male rats after oral administration of Zigbir® for 90 days.
| | Parameters | Control | 250 mg/kg | 500 mg/kg | 1000 mg/kg | Control recovery | 1000 mg/kg recovery |
| | Total protein (g%) | 7.55 ± 0.47 | 7.63 ± 0.48 | 7.66 ± 0.56 | 7.58 ± 0.51 | 7.47 ± 0.47 | 7.40 ± 0.28 | | Albumin (g%) | 3.42 ± 0.45 | 3.29 ± 0.43 | 3.49 ± 0.39 | 3.57 ± 0.42 | 3.65 ± 0.22 | 3.58 ± 0.26 | | Bilirubin (mg%) | 0.65 ± 0.07 | 0.68 ± 0.11 | 0.72 ± 0.08 | 0.69 ± 0.08 | 0.72 ± 0.08 | 0.66 ± 0.05 | | Blood sugar (mg%) | 88.50 ± 10.28 | 92.10 ± 10.64 | 90.90 ± 9.16 | 88.90 ± 8.27 | 96.40 ± 7.09 | 97.40 ± 12.28 | | Triglycerides (mg%) | 105.30 ± 8.56 | 102.10 ± 7.23 | 107.50 ± 7.43 | 108.20 ± 3.33 | 105.00 ± 4.64 | 107.20 ± 1.30 | | Cholesterol (mg%) | 61.30 ± 5.68 | 58.60 ± 2.72 | 63.30 ± 6.50 | 64.20 ± 4.98 | 63.80 ± 4.02 | 62.20 ± 6.30 | | BUN (mg%) | 37.20 ± 5.05 | 38.10 ± 7.14 | 41.10 ± 4.61 | 39.60 ± 6.36 | 40.20 ± 2.28 | 39.20 ± 4.44 | | Creatinine (mg%) | 0.99 ± 0.14 | 0.98 ± 0.11 | 0.99 ± 0.11 | 0.98 ± 0.10 | 1.02 ± 0.10 | 1.04 ± 0.14 | | AST (IU/L) | 62.00 ± 4.00 | 61.10 ± 4.58 | 60.90 ± 3.31 | 64.20 ± 4.76 | 61.80 ± 8.11 | 60.40 ± 6.19 | | ALT (IU/L) | 43.80 ± 6.56 | 38.90 ± 7.88 | 40.40 ± 8.96 | 41.50 ± 6.08 | 38.80 ± 3.19 | 37.60 ± 6.31 | | ALP (IU/L) | 68.80 ± 6.83 | 69.90 ± 5.99 | 70.80 ± 6.58 | 115.40** ± 12.40 | 73.00 ± 8.49 | 66.00 ± 5.10 | | γGT (U/L) | 14.10 ± 2.73 | 16.70 ± 4.50 | 14.80 ± 2.90 | 14.90 ± 3.28 | 18.80 ± 4.21 | 17.00 ± 1.58 | | LDH (IU/L) | 358.30 ± 31.75 | 354.00 ± 26.99 | 345.30 ± 28.80 | 361.60 ± 28.48 | 357.40 ± 32.26 | 337.00 ± 33.59 | | CPK (IU/L) | 63.40 ± 4.99 | 62.20 ± 4.96 | 67.20 ± 4.13 | 64.60 ± 3.57 | 63.40 ± 3.78 | 67.40 ± 2.97 | | Sodium (mmol/L) | 141.30 ± 5.62 | 142.20 ± 6.58 | 141.20 ± 6.71 | 136.50 ± 5.66 | 138.60 ± 1.14 | 140.40 ± 6.15 | | Chloride (mmol/L) | 101.60 ± 3.47 | 101.50 ± 2.92 | 101.80 ± 3.16 | 101.40 ± 2.88 | 102.20 ± 2.68 | 101.80 ± 2.77 | | Potassium (mmol/L) | 3.70 ± 0.35 | 3.58 ± 0.15 | 3.66 ± 0.22 | 3.75 ± 0.23 | 3.81 ± 0.10 | 3.84 ± 0.06 | | Calcium (mg%) | 9.64 ± 0.66 | 9.55 ± 0.51 | 9.63 ± 0.53 | 9.78 ± 0.74 | 9.96 ± 0.53 | 10.04 ± 0.72 | | Phosphorus (mg%) | 4.30 ± 0.32 | 4.31 ± 0.42 | 4.06 ± 0.28 | 4.08 ± 0.43 | 4.12 ± 0.57 | 4.34 ± 0.05 |
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P < 0.01 versus control group.
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