Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

Table 8

Relative organ weights (% of fasting body weight; mean ± SD) in male rats treated with Zigbir® orally for 90 days.

Organ	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control recovery	1000 mg/kg recovery
Terminal body weight (g)	348.86 ± 18.31	342.77 ± 28.01	332.90 ± 24.41	339.11 ± 32.83	367.32 ± 29.61	347.08 ± 37.86
Brain	0.568 ± 0.027	0.574 ± 0.039	0.571 ± 0.027	0.583 ± 0.060	0.536 ± 0.042	0.582 ± 0.056
Liver	3.331 ± 0.303	3.077 ± 0.280	3.083 ± 0.536	3.033 ± 0.384	2.412 ± 0.568	2.792 ± 0.570
Kidneys	0.743 ± 0.076	0.730 ± 0.058	0.711 ± 0.063	0.739 ± 0.043	0.676 ± 0.107	0.752 ± 0.139
Adrenals	0.0148 ± 0.003	0.0174 ± 0.003	0.0169 ± 0.002	0.0155 ± 0.003	0.0159 ± 0.003	0.0151 ± 0.003
Testes	0.829 ± 0.063	0.830 ± 0.094	0.906 ± 0.124	0.849 ± 0.116	0.725 ± 0.103	0.835 ± 0.179
Heart	0.324 ± 0.026	0.306 ± 0.016	0.298 ± 0.028	0.298 ± 0.027	0.271 ± 0.031	0.308 ± 0.044
Spleen	0.301 ± 0.062	0.331 ± 0.105	0.359 ± 0.098	0.349 ± 0.063	0.300 ± 0.099	0.341 ± 0.040
Lungs	0.461 ± 0.068	0.518 ± 0.067	0.478 ± 0.102	0.479 ± 0.062	0.411 ± 0.095	0.386 ± 0.181