Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage

Table 3

Assembled data on the effect of the bee and scorpion venom KTxs on the performance of animals in behavioral tests of learning and memory.

	Species	Toxin	KCN target	Behavioral test	Result	Ref.
Scorpion	Androctonus mauretanicus mauretanicus	Kaliotoxin	Kv1.1 and Kv1.3 blocker	Olfactory discrimination task in rats	Improvement	[92]
	Buthus tasmulus	Iberiotoxin (IbTx)	KCa1.1 blocker	Passive avoidance test in chicks	Impaired retention	[93]
	Leiurus quinquestriatus hebraeus	Charybdotoxin	Kv1.3 and KCa1.1 blocker	Passive avoidance test in mice	Improvement	[50]
		Lei-Dab7	KCa2.2 blocker	Radial arm maze in rat	No effect	[25]
Bee	Apis mellifera	Apamin	KCa2.2 and KCa2.3 blocker	Bar-pressing response in appetitively motivated mice	Improvement	[94]
				Object recognition task in rats	Improvement	[95]
				Habituation task in rats	Improvement	[96]
				Passive avoidance test in rats or mice	No effect	[96, 97]
				Passive avoidance test in mice	Improvement	[50, 98]
				Morris water maze in mice	Improvement	[97, 98]
				Morris water maze in rats	No effect	[98]
				Y-maze test in mice	No effect	[97]
				Radial arm maze test in mice or rats	Improvement	[25, 99]
				Visual discrimination in rats	No effect	[98]
				Olfactory discrimination task in rats	Improvement	[100]
				Olfactory associative task in rats	Improvement	[101]
				Tone fear-conditioning paradigm in mice	No effect	[53]
				T-maze test in rats	Improvement	[102]
				Passive avoidance task in chicks	Impaired retention	[103]

Ref.: reference.