Reconstruction of Exposure to m-Xylene from Human Biomonitoring Data Using PBPK Modelling, Bayesian Inference, and Markov Chain Monte Carlo Simulation

Table 1

Individual volunteer parameters.

Volunteer	Age	Body weight (BW) (kg)	Height (m)	BMI (kg/m^2)	Mass of body fat (VfaC); (% (BW))	Resting alveolar ventilation rate (QPC) (l/hr)	Urine flow (Rurine) (l/hr)	Urinary creatinine (CRE); (mmol/l)	m-Xylene blood : air partition coefficient (Pba)
A	54	79	1.68	28.00	0.218	383.3	0.070	14.8	15.1
B	51	61.5	1.78	19.32	0.192	409.3	0.125	7.30	16.8
C	47	89	1.91	24.40	0.169	477.5	0.090	14.9	11.4
D	48	85	1.75	27.80	0.263	362.7	0.091	13.0	18.0
E	29	76	1.85	22.20	0.130	327.2	0.088	12.5	26.5
F	25	76	1.83	22.70	0.162	352.6	0.055	14.8	20.2
G	41	75	1.70	26.00	0.179	462.2	0.076	12.8	—
H	29	68	1.70	23.50	0.299	348.6	0.074	10.2	21.6
Mean		76.2	1.78	24.24	0.202	390.4	0.083	12.5	18.5
SD		8.73	0.08	2.95	0.056	54.89	0.021	2.70	4.90
CV		0.115	0.05	0.122	0.277	0.141	0.247	0.212	0.26