|
| Parameter | Abbreviation | Value | Distribution |
|
| Molecular mass m-xylene (g/mol) | MWxyl | 106.17 | — |
| Molecular mass MHA (g/mol) |
MWMHA | 193.2 | — |
| Body mass (kg) | BW | | Normal BW~N(76.2, (8.73)2) |
| Vascularised tissue (proportion of body mass) | VT | 0.91 | — |
| Cardiac output (L h−1 BW−0.75) | QCC | | Normal QCC~N(13.8, (2.5)2) |
| Metabolism (Liver) | | | |
| In vitro Michaelis constant (mMol L−1) | KM | | Normal KM ~N(11.8, (1.4)2) |
In vitro maximum rate of metabolism (pmol min−1 mg−1
microsomal protein) | | | Normal (895, (68)2) |
| Microsomal protein yield per gram wet weight liver (mg g−1) | MPY | | Lognormal ln (MPY)~N(3.7, (2.9)2) |
| Gas exchange | | | |
| Respiratory rate (L h−1) | QPC | | Normal QPC~N(390.4, (54.9)2) |
| Respiratory dead space (proportion respiratory rate) | DS | 0.3 | — |
| Partition coefficient | | | |
| Blood : air partition coefficient | Pba | | Normal Pba~N(18.5, (4.9)2) |
| Rapidly perfused | Prpda | | Uniform Prpda~U(50–150) |
| Slowly perfused | Pspda | | Uniform Pspda~U(40–80) |
| Adipose | Pfaa | | Uniform Pfaa~U(1400–2200) |
| Liver | Plia | | Uniform Plia~U(150–350) |
| Tissue blood flow as a fraction of cardiac output | | | |
| Rapidly perfused | QrpdC | 0.48 | — |
| Slowly perfused | QspdC | 0.22 | Uniform QspdC~U(0.2–0.35) |
| Adipose | QfaC | 0.05 | Normal QfaC~N(0.053,(0.003)2) |
| Liver | QliC | 0.25 | Normal QliC~N(0.271,(0.01)2) |
| Tissue mass as a fraction of body mass | | | |
| Rapidly perfused | VrpdC | 0.09 | — |
| Slowly perfused | VspdC | 0.604 | — |
| Adipose | VfaC | 0.19 | Lognormal ln(VfaC)~N(−1.59,(−2.88)2) |
| Liver | VliC | 0.0257 | Normal VliC~N(0.036,(0.01)2) |
| Bladder compartment | | | |
| Rate of urine production (L h−1) |
Rurine | 0.07 | Normal (0.083,(0.021)2) |
| Urinary creatinine concentration (mmol L−1) | CRE | 12.5 | Normal CRE~N(12.5,(2.7)2) |
| First-order elimination rate constant (h−1) | K1 | | Uniform K1~U(5–20) |
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