Journal of Toxicology / 2012 / Article / Tab 1

Review Article

The Adverse Effects of Air Pollution on the Nervous System

Table 1

The effects of air pollutants on neuronal and glial cells in vitro.

PollutantsSpeciesCell typeAssaysKey findingsReferences

PMs
DEPsRatVM Neuron-gliaTH immunostainingDA neurotoxicity [46]
OX-42 immunostainingMicroglial activation
Mouse
(PHOX−/−)
MicrogliaDCFH-DAIncreased microglial ROS
MicrogliaDA uptakeNo DEP neurotoxicity
DEPs + LPSRatVM Neuron-gliaGriess reactionIncreased NO production [49]
RatHAPI microglialTH immunostainingDA neurotoxicity
cell lineELISAIncreased TNFα release
DEPsRatBrain capillariesCM-H2DCFDAIncreased ROS production [47]
ELISAIncreased TNFα release
CAPsMouseBV2 microglial cell lineELISAIncreased TNFα, IL6 release
Increased P-glycoprotein
[50]
Western blotting microarrayUpregulated inflammatory genes

OzoneRatAstrocyteMDAIncreased lipid peroxidation [48]
LDHDecreased cell viability

Abbreviations: concentrated ambient particles (CAPs), 2′,7′-dichlorfluorescein-diacetate (DCFH-DA), dopaminergic (DA), diesel exhaust particles (DEPs), enzyme-linked immunosorbent assay (ELISA), interleukin-6 (IL-6), lactate dehydrogenase (LDH), malondialdehyde (MDA) nitric oxide (NO), reactive oxygen species (ROS), tyrosine hydroxylase (TH), tumor necrosis factor alpha (TNFα), ventral mesencephalic (VM).

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