Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment
Figure 7
Simulated end-of-exposure nonhuman primate globus pallidus manganese concentrations following a 24 h/d, 7 d/wk inhalation for either 90 days (subchronic) or 2 yr (chronic) exposure to MnSO4. These simulations indicate that globus pallidus manganese concentrations are expected to rapidly reach pseudosteady-state levels during high dose manganese exposure, and that duration of exposure has a minimal effect. Its contribution only occurs once exposures reach the threshold to cause tissue accumulation.
