Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels

Figure 2

Hypothesis on deglycosylation-created modulation of scorpion toxins to VGSCs. For glycosylated VGSC, the sialic carbohydrates (dotted branch) shield the binding site and thus prevent toxin binding (left). If the sialic carbohydrates are deleted, the toxin accessibility to the binding site is facilitated because of the absence of the oligosaccharide groups and consequently modulate the gating of VGSCs (right).