In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients

Table 1

Ingredients contained in popular cold medicines available in Japan. Chinese herbs, vitamins, and lysozyme are excluded from the table.

Drug name	Therapeutic category
Acetaminophen	Analgesic; antipyretic
Ambroxol	Expectorant
Bromhexine	Expectorant; mucolytic
Caffeine	CNS stimulant; respiratory stimulant
Carbinoxamine	Antihistaminic
d-Chlorpheniramine	Antihistaminic
Clemastine	Antihistaminic
Dextromethorphan	Antitussive
Dihydrocodeine	Analgesic (narcotic); antitussive
Ethenzamide	Analgesic
Guaiacol	Expectorant
Guaifenesin	Expectorant
Ibuprofen	Anti-inflammatory; analgesic; antipyretic
Isopropamide	Antispasmodic
Loxoprofen (R, S)	Anti-inflammatory; analgesic
Mequitazine	Antihistaminic
d-Methylephedrine	Analeptic
Noscapine	Antitussive
Pseudoephedrine	Decongestant
Tranexamic acid	Hemostatic