Effect of Aqueous Stem Bark Extract of Khaya senegalensis on Some Biochemical, Haematological, and Histopathological Parameters of Rats

Table 3

Effect of subchronic oral administration of aqueous stem bark extract of K. senegalensis on liver function parameters of Albino rats.

Test	0 mg/kg bw	400 mg/kg bw	800 mg/kg bw	1200 mg/kg bw	1600 mg/kg bw	2000 mg/kg bw
T. protein (g/dL)	9.56±0.64	9.09±0.22	8.30±0.35^b	8.04±0.22^b	7.98±0.18^b	7.59±0.36^b
Albumin (g/dL)	5.31±0.44	4.08±0.21^b	4.05±0.21^b	3.99±0.33^b	4.24±0.22^b	4.35±0.30^b
Globulin (g/dL)	4.16±0.23	4.85±0.24^b	4.25±0.22	4.08±0.17	3.70±0.21^b	3.09±0.29^b
A : G ratio	1.32±0.22	0.89±0.10^b	0.96±0.14^b	0.98±0.10^b	1.12±0.12	1.49±0.16
AST(U/I)	52.44±2.50	54.15±2.87	59.60±2.60^b	58.07±3.35^b	61.24±3.61^b	84.06±3.63^b
ALT (U/I)	32.54±2.50	37.58±3.26	44.17±3.10^b	51.53±3.00^b	53.22±2.83^b	60.18±3.40^b
ALP (U/I)	124.74±8.72	126.41±12.56	135.42±12.25^b	149.43±6.80^b	198.40±2.60^b	287.93±51.80^b
T. BlL (mg/dL)	1.17±0.61	1.92±0.89	2.13±0.71^b	1.72±0.91^b	3.96±0.60^b	4.26±0.49^b
C. BIL (mg/dL)	0.91±0.36	0.37±0.21^b	0.76±0.29^b	0.42±0.17^b	1.40±0.29^b	1.47±0.27^b
U. BIL (mg/dL)	0.26±0.25	1.46±0.36^b	1.36±0.32^b	1.29±0.43^b	2.45±0.47^b	2.88±0.56^b

Values are expressed as mean ± SD; 𝑛=5. The level of significance was set at ^b𝑃<0.05 when compared with control at 0 mg/kg body weight, Dunnett’s multiple comparison test.