Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

Figure 5

Influence of 2,5-HD on kidney morphology after treatment for 21 consecutive days in rats. Representative photomicrographs of control (a) show normal renal architecture. Kidney histology revealed progressive degeneration of the proximal tubules characterized by mild hemorrhage (green chevron) at interstitium in tubular epithelial cells in 0.25% 2,5-HD (b) and severe vacuolation and renal tubular necrosis (blue chevron) in 0.5% 2,5-HD (c) and 1% 2,5-HD (d).

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