Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

Table 2

Biomarkers of hepatic dysfunction in rats exposed to 2,5-hexanedione for 21 days.

Endpoints	Control	0.25% 2,5-HD	0.50% 2,5-HD	1.0% 2,5-HD
AST (U/L)	21.50 ± 0.71	32.50 ± 0.71*	39.50 ± 2.89*	41.08 ± 1.41*
ALT (U/L)	19.33 ± 1.15	24.50 ± 3.11*	26.73 ± 1.15*	27.50 ± 0.71*
ALP (U/L)	18.33 ± 2.08	23.69 ± 1.15	25.50 ± 4.95*	29.03 ± 6.68*
Albumin (g/L)	26.50 ± 1.29	27.10 ± 2.00	28.04 ± 0.82	28.40 ± 1.67
Conjugated bilirubin (mmol/L)	1.75 ± 0.89	1.87 ± 0.53	2.63 ± 0.55*	2.40 ± 0.55*
Total bilirubin (mmol/L)	3.75 ± 0.96	5.75 ± 0.96*	7.20 ± 1.00*	7.75 ± 1.71*

ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase. The data are expressed as mean ± SD for eight animals per group. * < 0.05 against control.