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Journal of Toxicology
Volume 2014, Article ID 406242, 7 pages
http://dx.doi.org/10.1155/2014/406242
Research Article

Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera

1Molecular Cancer Biology Research Group, Molecular Pathology and Immunology Division, Department of Medical Laboratory Sciences, School of Biomedical Science, Faculty of Health Science, Ebonyi State University, Nigeria
2Cancer Research Unit, Saskatchewan Cancer Agency, Room A 231, Health Science Building, University of Saskatchewan, Saskatoon, SK, Canada S7N 5R5
3Department of Pathology and Molecular Medicine and Department of Cell Physiology and Pharmacology, University of Leicester, UK

Received 24 July 2014; Revised 12 November 2014; Accepted 18 November 2014; Published 8 December 2014

Academic Editor: Margaret James

Copyright © 2014 Maxwell Omabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Moringa oleifera (MO) is used for a number of therapeutic purposes. This raises the question of safety and possible toxicity. The objective of the study was to ascertain the safety and possible metabolic toxicity in comparison with metformin, a known drug associated with acidosis. Animals confirmed with diabetes were grouped into 2 groups. The control group only received oral dose of PBS while the test group was treated with ethanolic extract of MO orally twice daily for 5-6 days. Data showed that the extract significantly lowered glucose level to normal values and did not cause any significant cytotoxicity compared to the control group (); there was no gain in weight between the MO treated and the control groups (). However, data showed that treatment with an ethanolic extract of MO caused a decrease in bicarbonate (), and more than twofold increase in anion gap (); metformin treatment also decreased bicarbonate () and resulted in a threefold increase in anion gap (). Conclusively, these data show that while MO appears to have antidiabetic and noncytotoxic properties, it is associated with statistically significant anion gap acidosis in alloxan induced type 2 diabetic rats.