Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2014, Article ID 412437, 5 pages
Research Article

Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques

1Aquaculture Center of UNESP, Jaboticabal, SP, Brazil
2Department of Veterinary Pathology, School of Agrarian and Veterinary Sciences, São Paulo State University (UNESP), 14884-900 Jaboticabal, SP, Brazil
3Weed Science Environmental Research Studies Centre of UNESP, University Estadual Paulista, Jaboticabal, SP, Brazil
4Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

Received 5 November 2013; Accepted 16 January 2014; Published 6 March 2014

Academic Editor: Robert Luebke

Copyright © 2014 Jefferson Yunis Aguinaga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Keplinger, G. Laus, M. Wurm, M. P. Dierich, and H. Teppner, “Uncaria tomentosa (Willd.) DC.—ethnomedicinal use and new pharmacological, toxicological and botanical results,” Journal of Ethnopharmacology, vol. 64, no. 1, pp. 23–34, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Eberlin, L. M. B. Dos Santos, and M. L. S. Queiroz, “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes,” International Immunopharmacology, vol. 5, no. 7-8, pp. 1235–1246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. V. J. Smith, J. H. Brown, and C. Hauton, “Immunostimulation in crustaceans: does it really protect against infection?” Fish and Shellfish Immunology, vol. 15, no. 1, pp. 71–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. G. S. Claudiano, J. Dias, R. Sakabe et al., “Eficácia do extrato aquoso de “Terminalia catappa” em juvenis de tambaqui parasitados por monogenéticos e protozoários,” Revista Brasileira de Saúde e Produção Animal, vol. 10, pp. 625–636, 2009. View at Google Scholar
  5. C. Pavei, S. Kaiser, G. L. Borré, and G. G. Ortega, “Validation of a LC method for polyphenols assay in cat's claw (Uncaria tomentosa),” Journal of Liquid Chromatography and Related Technologies, vol. 33, no. 17, pp. 1551–1561, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Kaiser, S. Gasparin, R. Cougo et al., “Cat’s claw oxindole alkaloid isomerization induced by common extraction methods,” Química Nova, vol. 36, pp. 1–7, 2013. View at Google Scholar
  7. C. Pavei, S. Kaiser, S. G. Verza, G. L. Borre, and G. G. Ortega, “HPLC-PDA method for quinovic acid glycosides assay in Cat's claw (Uncaria tomentosa) associated with UPLC/Q-TOF-MS analysis,” Journal of Pharmaceutical and Biomedical Analysis, vol. 62, pp. 250–257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. Associação Brasileira de Normas Técnicas, NBR 10007: Amostragem De Resíduos—Procedimento, Associação Brasileira de Normas Técnicas, Rio de Janeiro, Brazil, 2011.
  9. Companhia de Tecnologia de Sanemento Ambiental do Estado de São Paulo, Métodos de Avaliação da Toxicidade de Poluentes a Organismos Aquáticos. Água-Teste de Toxicidade Aguda com Peixes—parte I—Sistema estático, vol. 2, Companhia de Tecnologia de Sanemento Ambiental do Estado de São Paulo, São Paulo, Brazil, 1999.
  10. P. Montoro, V. Carbone, J. de Dioz Zuniga Quiroz, F. De Simone, and C. Pizza, “Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS,” Phytochemical Analysis, vol. 15, no. 1, pp. 55–64, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Zucker, Hazard Evaluation Division Standard Evaluation Procedure: Acute Toxicity Test for Freshwater Fish, U.S. Environmental Protection Agency, Office of Pesticide Programs, 1985.
  12. E. Winkaler, J. Machado, and C. Martinez, “Toxicidade e efeitos do extrato aquoso de folhas secas de nim (Azadirachta indica) em parâmetros fisiológicos de tilápias do Nilo,” Anais do (ZOOTEC '05), 2005,
  13. G. S. Claudiano, F. Pilarski, C. Cruz, R. Salvador, M. A. A. Belo, and F. R. Moraes, “Concentração letal CL50 do extrato aquoso de folhas de Terminalia catappa em guaru, Phalloceros caudimaculatus,” Archives of Veterinary Science, vol. 17, pp. 15–19, 2012. View at Google Scholar
  14. W. K. Milsom, “Afferent inputs regulating ventilation in vertebrates,” in The Vertebrate Gas Transport Cascade. Adaptations and Mode of Life, J. E. P. W. Bicudo, Ed., pp. 94–105, CRC Press, Boca Raton, Fla, USA, 1993. View at Google Scholar
  15. I. Sakakibara, S. Terabayashi, M. Kubo et al., “Effect on locomotion of indole alkaloids from the hooks of Uncaria plants,” Phytomedicine, vol. 6, no. 3, pp. 163–168, 1999. View at Google Scholar · View at Scopus