Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine
(a) The control group with preserved hepatic architecture (H&E ×200). (b) METH injections caused by a hoop of oedema in the periportal area (arrowhead), which compressed the surrounding hepatocytes. The intracytoplasm vacuolation was found (H&E ×400). (c) Pretreatment of chlorogenic acidwith preserved hepatic lobular architecture. The hepatocytes are within normal limit and preserved its plate pattern. Liver almost returns to the normal pattern (H&E ×200). (d) Pretreatment of caftaric acid to METH injected rats with large reserved hepatic lobular architecture and the liver almost returns to the normal pattern (H&E ×200).