Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 4

Effect of chlorogenic and caftaric acids on blood SOD and GPx, serum MDA, and plasma NO of METH-injected rats.

Groups	Parameters
	SOD; (U/mL)	GPx; (U/L)	MDA; (μmol/L)	NO; (μmol/L)
Control	260 ± 8.39	6250 ± 82.95	3.51 ± 0.26	35.8 ± 1.78
METH group	236.9 ± 7.86*	5985 ± 98.71*	5.76 ± 0.54**	50.1 ± 2.25**
Chlorogenic acid + METH group	258.7 ± 8.63^a	6240 ± 86.93^a	3.54 ± 0.38^b	37.0 ± 1.98^b
Caftaric acid + METH group	265.1 ± 7.91^a	6435 ± 100.14^b	3.71 ± 0.42^b	40.5 ± 1.86^a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change (𝑃≤0.05) compared to control rats.
**Highly significant change (𝑃≤0.01) compared to control rats.
^aSignificant change (𝑃≤0.05) compared to METH group.
^bHighly significant change (𝑃≤0.01) compared to METH group.