Journal of Toxicology / 2014 / Article / Tab 4

Research Article

Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 4

Effect of chlorogenic and caftaric acids on blood SOD and GPx, serum MDA, and plasma NO of METH-injected rats.

Groups Parameters
SOD
(U/mL)
GPx
(U/L)
MDA
(μmol/L)
NO
(μmol/L)

Control260 ± 8.396250 ± 82.953.51 ± 0.2635.8 ± 1.78
METH group236.9 ± 7.86*5985 ± 98.71*5.76 ± 0.54**50.1 ± 2.25**
Chlorogenic acid + METH group258.7 ± 8.63a6240 ± 86.93a3.54 ± 0.38b37.0 ± 1.98b
Caftaric acid + METH group265.1 ± 7.91a6435 ± 100.14b3.71 ± 0.42b40.5 ± 1.86a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change compared to control rats.
**Highly significant change compared to control rats.
aSignificant change compared to METH group.
bHighly significant change compared to METH group.