Journal of Toxicology / 2014 / Article / Tab 6

Research Article

Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 6

Effect of chlorogenic and caftaric acids on serotonin, norepinephrine, dopamine, and MDA in the brain cerebral cortex of METH-injected rats.

Groups Parameters
Serotonin
(µg/gm tissue)
Norepinephrine
(µg/gm tissue)
Dopamine
(µg/gm tissue)
MDA
(nmol/mg tissue)

Control0.56 ± 0.052.49 ± 0.190.27 ± 0.0134.85 ± 5.16
METH group0.32 ± 0.10**1.02 ± 0.13**0.14 ± 0.03**47.13 ± 8.63*
Chlorogenic acid + METH group0.54 ± 0.08b2.46 ± 0.08b0.25 ± 0.05b36.25 ± 6.09a
Caftaric acid + METH group0.50 ± 0.05a2.44 ± 0.11b0.21 ± 0.04a38.54 ± 5.42a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change compared to control rats.
**Highly significant change compared to control rats.
aSignificant change compared to METH group.
bHighly significant change compared to METH group.