Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 6

Effect of chlorogenic and caftaric acids on serotonin, norepinephrine, dopamine, and MDA in the brain cerebral cortex of METH-injected rats.

Groups	Parameters
	Serotonin; (µg/gm tissue)	Norepinephrine; (µg/gm tissue)	Dopamine; (µg/gm tissue)	MDA; (nmol/mg tissue)
Control	0.56 ± 0.05	2.49 ± 0.19	0.27 ± 0.01	34.85 ± 5.16
METH group	0.32 ± 0.10**	1.02 ± 0.13**	0.14 ± 0.03**	47.13 ± 8.63*
Chlorogenic acid + METH group	0.54 ± 0.08^b	2.46 ± 0.08^b	0.25 ± 0.05^b	36.25 ± 6.09^a
Caftaric acid + METH group	0.50 ± 0.05^a	2.44 ± 0.11^b	0.21 ± 0.04^a	38.54 ± 5.42^a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change (𝑃≤0.05) compared to control rats.
**Highly significant change (𝑃≤0.01) compared to control rats.
^aSignificant change (𝑃≤0.05) compared to METH group.
^bHighly significant change (𝑃≤0.01) compared to METH group.