Botulinum Toxin Suppression of CNS Network Activity In Vitro
Figure 4
Characteristic response profiles from two different CNS tissues and two different concentrations of BoNT-A. (a) Spinal cord network exposed to 12 ng/mL showing a latency of 100 min and a 90% decrease in 500 min. (b) Frontal cortex network exposed to 100 ng/mL showing a latency of 110 min and a 90% activity decrease in 290 min. (c) Dual networks from age- and maintenance-matched frontal cortex tissue exposed to 50 and 100 ng/mL simultaneously. The higher BoNT-A concentration decreased activity more rapidly, reaching 50% inhibition at 110 min and 175 min for 50 and 100 ng/mL, respectively.
